Multiple sclerosis is considered to be initiated by a deregulated, myelin-specific T cell
response. However, the formation of inflammatory CNS lesions and the contribution of …

Multiple sclerosis (MS) is believed to be initiated when myelin-specific T cells infiltrate the
central nervous system (CNS), triggering subsequent recruitment of inflammatory leukocytes …

Multiple sclerosis (MS) is a debilitating neurological disorder of the central nervous system
(CNS), characterized by activation and infiltration of leukocytes and dendritic cells into the …

Specialized populations of tissue-resident myeloid cells inhabit every organ of the body.
While many of these populations appear similar morphologically and phenotypically, they …

Objective Myeloid cells, including macrophages and dendritic cells, are a prominent
component of central nervous system (CNS) infiltrates during multiple sclerosis (MS) and the …

Macrophages can be of dual origin. Most tissue-resident macrophage compartments are
generated before birth and subsequently maintain themselves independently from each …

Animal models of autoimmune diseases such as experimental autoimmune
encephalomyelitis (EAE) are inflammatory demyelinating diseases which comprise a …

Multiple sclerosis (MS), an immune-mediated demyelinating disease of the central nervous
system (CNS), initially presents with a relapsing-remitting disease course. During this early …

Multiple sclerosis (MS) is a chronic autoimmune disease that affects the myelination of the
neurons present in the central nervous system (CNS). The exact etiology of MS development …

In both multiple sclerosis and its model experimental autoimmune encephalomyelitis (EAE),
the extent of resident microglia activation and infiltration of monocyte-derived cells to the …