Abstract Background & Aims Luteolin has been reported to exert antifibrogenic effects in CC
l4‐induced hepatic fibrosis in mice. However, limited information is available on the cellular …

Background β-sitosterol is a cholesterol-like phytosterol, which widely distributed in the plant
kingdom. Here, anti-fibrotic effect of the β-sitosterol was studied using the activated human …

Activation of hepatic stellate cells (HSCs) plays a critical role in liver fibrosis. Scoparone, a
major constituent isolated from Artemisia capillaris, was reported to possess …

Background and Aims: Tanshinol is a water-soluble bioactive monomer purified from the
dried root of Salvia miltiorrhiza and has been reported to exert hepatoprotective efficacy in …

METHODS: Male Sprague-Dawley rats underwent common bile duct ligation (BDL) for 14 d
and were treated with Gardenia jasminoides by gavage. The effects of Gardenia …

This study was carried out to investigate whether rosmarinic acid (RA) has antifibrotic effect
on experimental liver fibrosis in vitro and in vivo and its possible mechanism. Culture of …

During chronic liver injury, hepatic stellate cells (HSC) are activated and proliferate, which
causes excessive extracellular matrix (ECM) deposition, leading to scar formation and …

Although many advances have been made in understanding the pathogenesis of liver
fibrosis, few options are available for treatment. Casticin, one of the major flavonoids in …

Abstract Background and Aim Liver fibrosis is a worldwide clinical challenge during the
progression of chronic liver disease to liver cirrhosis. Shikonin is extracted from the root of …

Hepatic stellate cells (HSCs) are key mediators of fibrogenesis, and the regulation of their
activation is now viewed as an attractive target for the treatment of liver fibrosis. Here, the …