Physalin D attenuates hepatic stellate cell activation and liver fibrosis by blocking TGF-β/Smad and YAP signaling

D Xiang, J Zou, X Zhu, X Chen, J Luo, L Kong, H Zhang - Phytomedicine, 2020 - Elsevier
Background Hepatic fibrosis is considered integral to the progression of chronic liver
diseases, as it leads to the development of cirrhosis and hepatocellular carcinoma. The …

Jiawei Taohe Chengqi Decoction attenuates hepatic fibrosis by preventing activation of HSCs through regulating Src/ERK/Smad3 signal pathway

Y Huang, ZL Wang, Y He, LM Ye, WQ Guo… - Journal of …, 2023 - Elsevier
Abstract Ethnopharmacological relevance Jiawei Taohe Chengqi Decoction (JTCD) is a
Traditional Chinese Medicine (TCM) formula modified from Taohe Chengqi Decoction in the …

Phillygenin Inhibits TGF-β1-induced Hepatic Stellate Cell Activation and Inflammation: Regulation of the Bax/Bcl-2 and Wnt/β-catenin Pathways

C Wang, S Zhang, Y Li, L Gong, C Yao, K Fu, Y Li - Inflammation, 2024 - Springer
Hepatic fibrosis (HF), a precursor to cirrhosis and hepatocellular carcinoma, is caused by
abnormal proliferation of connective tissue and excessive accumulation of extracellular …

Naringenin attenuates the progression of liver fibrosis via inactivation of hepatic stellate cells and profibrogenic pathways

E Hernández-Aquino, MA Quezada-Ramírez… - European Journal of …, 2019 - Elsevier
There is no effective treatment for hepatic fibrosis. Previously, we demonstrated that
naringenin possesses the ability to prevent experimental chronic liver damage. Therefore …

Targeted blockade of JAK/STAT3 signaling inhibits proliferation, migration and collagen production as well as inducing the apoptosis of hepatic stellate cells

YJ Gu, WY Sun, S Zhang, XR Li… - … journal of molecular …, 2016 - spandidos-publications.com
Protein tyrosine kinases belonging to the Janus kinase (JAK) family are associated with
many cytokine receptors, which, on ligand binding, regulate important cellular functions such …

Salidroside ameliorates autophagy and activation of hepatic stellate cells in mice via NF-κB and TGF-β1/Smad3 pathways

J Feng, K Chen, Y Xia, L Wu, J Li, S Li… - Drug Design …, 2018 - Taylor & Francis
Purpose Liver fibrosis is commonly seen and a necessary stage in chronic liver disease. The
aim of this study was to explore the effect of salidroside on liver fibrosis in mice and its …

The Effects of Freshwater Clam (Corbicula fluminea) Extract on Activated Hepatic Stellate Cells

SL Lee, WH Hsu, CM Tu, WH Wang… - Evidence‐Based …, 2021 - Wiley Online Library
Background. The extract of freshwater clams has been used to protect the body against liver
diseases in traditional folk medicine. This study aims at investigating the effects of freshwater …

Asiatic Acid Inhibits Liver Fibrosis by Blocking TGF-beta/Smad Signaling In Vivo and In Vitro

L Tang, R He, G Yang, J Tan, L Zhou, X Meng… - PloS one, 2012 - journals.plos.org
Liver fibrosis is a major cause of liver failure, but treatment remains ineffective. In the present
study, we investigated the mechanisms and anti-hepatofibrotic activities of asiatic acid (AA) …

Tetramethylpyrazine reduces inflammation in liver fibrosis and inhibits inflammatory cytokine expression in hepatic stellate cells by modulating NLRP 3 inflammasome …

X Wu, F Zhang, X Xiong, C Lu, N Lian, Y Lu… - IUBMB life, 2015 - Wiley Online Library
Hepatic fibrosis is concomitant with liver inflammation, which has been highlighted as
significant treatment of chronic liver disease. We previously demonstrated that …

Quercetin improves hepatic fibrosis reducing hepatic stellate cells and regulating pro‐fibrogenic/anti‐fibrogenic molecules balance

LD Hernández‐Ortega… - Journal of …, 2012 - Wiley Online Library
Abstract Background and Aim Development of hepatic cirrhosis involves oxidative stress,
inflammation, hepatic stellate cells (HSC) s activation and fibrosis. On the other hand …