Identifying the transition of relapsing-remitting multiple sclerosis (MS) to the secondary-
progressive MS form remains a clinical challenge due to the gradual nature of the transition …

Many challenges exist in the precise diagnosis and clinical management of secondary
progressive multiple sclerosis (SPMS) because of the lack of definitive clinical, imaging …

Upon the approval of disease-modifying therapies (DMTs) for patients with active secondary
progressive phase of multiple sclerosis (SPMS), there became an emerging need to …

Despite the fact that majority of patients with multiple sclerosis (MS) have relapsing-remitting
disease, many transition to secondary progressive disease (SPMS) over time. This transition …

PURPOSE OF REVIEW This article provides an update on progressive forms of multiple
sclerosis (MS) commonly referred to as primary progressive MS and secondary progressive …

In most cases, multiple sclerosis (MS) begins with a relapsing-remitting course followed by
insidious disability worsening that is independent from clinically apparent relapses and is …

Abstract Background and Purpose Multiple sclerosis (MS) is an unpredictable disease
characterised by a highly variable disease onset and clinical course. Three main clinical …

Available therapies for multiple sclerosis patients, while effective during the relapsing phase,
have little benefit for progressive multiple sclerosis patients. Development of therapies to …

Secondary progressive multiple sclerosis (SPMS) is diagnosed retrospectively and involves
a clinical course characterized by a progressive accumulation of neurological disability …

Abstract Purpose of Review: Many therapeutic advances for relapsing-remitting multiple
sclerosis (MS) have occurred in the past 25 years. Although similar advances in disease …