Inhibition of gastric inhibitory polypeptide receptor signaling in adipose tissue reduces insulin resistance and hepatic steatosis in high-fat diet–fed mice
E Joo, N Harada, S Yamane, T Fukushima, D Taura… - Diabetes, 2017 - Am Diabetes Assoc
Gastric inhibitory polypeptide receptor (GIPR) directly induces energy accumulation in
adipose tissue in vitro. However, the importance of the direct effect of GIPR signaling on …
adipose tissue in vitro. However, the importance of the direct effect of GIPR signaling on …
Inhibition of GIP signaling modulates adiponectin levels under high-fat diet in mice
R Naitoh, K Miyawaki, N Harada, W Mizunoya… - Biochemical and …, 2008 - Elsevier
Gastric inhibitory polypeptide (GIP) is an incretin and directly promotes fat accumulation in
adipocytes. Inhibition of GIP signaling prevents onset of obesity and increases fat oxidation …
adipocytes. Inhibition of GIP signaling prevents onset of obesity and increases fat oxidation …
Gastric inhibitory polypeptide modulates adiposity and fat oxidation under diminished insulin action
H Zhou, Y Yamada, K Tsukiyama, K Miyawaki… - Biochemical and …, 2005 - Elsevier
Gut hormone gastric inhibitory polypeptide (GIP) stimulates insulin secretion from pancreatic
β-cells upon ingestion of nutrients. Inhibition of GIP signaling prevents the onset of obesity …
β-cells upon ingestion of nutrients. Inhibition of GIP signaling prevents the onset of obesity …
[HTML][HTML] Physiological roles of the GIP receptor in murine brown adipose tissue
Objective Glucose-dependent insulinotropic polypeptide (GIP) is secreted from the gut in
response to nutrient ingestion and promotes meal-dependent insulin secretion and lipid …
response to nutrient ingestion and promotes meal-dependent insulin secretion and lipid …
GIP receptor deletion in mice confers resistance to high-fat diet-induced obesity via alterations in energy expenditure and adipose tissue lipid metabolism
Glucose-dependent insulinotropic polypeptide (GIP) is best known as an incretin hormone
that is secreted from K-cells of the proximal intestine, but evidence also implicates a role for …
that is secreted from K-cells of the proximal intestine, but evidence also implicates a role for …
Gastric inhibitory polypeptide receptor antagonism suppresses intramuscular adipose tissue accumulation and ameliorates sarcopenia
Y Takahashi, H Fujita, Y Seino, S Hattori… - Journal of Cachexia …, 2023 - Wiley Online Library
Background Intramuscular adipose tissue (IMAT) formation derived from muscle fibro‐
adipogenic progenitors (FAPs) has been recognized as a pathological feature of …
adipogenic progenitors (FAPs) has been recognized as a pathological feature of …
[HTML][HTML] Chemical gastric inhibitory polypeptide receptor antagonism protects against obesity, insulin resistance, glucose intolerance and associated disturbances in …
Aims/hypothesis Gastric inhibitory polypeptide (GIP) receptor antagonism with (Pro 3) GIP
improves glucose tolerance and ameliorates insulin resistance and abnormalities of islet …
improves glucose tolerance and ameliorates insulin resistance and abnormalities of islet …
GIP receptor antagonism reverses obesity, insulin resistance, and associated metabolic disturbances induced in mice by prolonged consumption of high-fat diet
PL McClean, N Irwin, RS Cassidy… - American Journal …, 2007 - journals.physiology.org
The gut hormone gastric inhibitory polypeptide (GIP) plays a key role in glucose
homeostasis and lipid metabolism. This study investigated the effects of administration of a …
homeostasis and lipid metabolism. This study investigated the effects of administration of a …
Genetic inactivation of GIP signaling reverses aging-associated insulin resistance through body composition changes
C Yamada, Y Yamada, K Tsukiyama, K Yamada… - Biochemical and …, 2007 - Elsevier
Aging is associated with increased fat mass and decreased lean mass, which is strongly
associated with the development of insulin resistance. Gastric inhibitory polypeptide (GIP) is …
associated with the development of insulin resistance. Gastric inhibitory polypeptide (GIP) is …
Anti-obesity effects of GIPR antagonists alone and in combination with GLP-1R agonists in preclinical models
Glucose-dependent insulinotropic polypeptide (GIP) receptor (GIPR) has been identified in
multiple genome-wide association studies (GWAS) as a contributor to obesity, and GIPR …
multiple genome-wide association studies (GWAS) as a contributor to obesity, and GIPR …
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