Inhibition of gastric inhibitory polypeptide receptor signaling in adipose tissue reduces insulin resistance and hepatic steatosis in high-fat diet–fed mice

E Joo, N Harada, S Yamane, T Fukushima, D Taura… - Diabetes, 2017 - Am Diabetes Assoc
Gastric inhibitory polypeptide receptor (GIPR) directly induces energy accumulation in
adipose tissue in vitro. However, the importance of the direct effect of GIPR signaling on …

Inhibition of GIP signaling modulates adiponectin levels under high-fat diet in mice

R Naitoh, K Miyawaki, N Harada, W Mizunoya… - Biochemical and …, 2008 - Elsevier
Gastric inhibitory polypeptide (GIP) is an incretin and directly promotes fat accumulation in
adipocytes. Inhibition of GIP signaling prevents onset of obesity and increases fat oxidation …

Gastric inhibitory polypeptide modulates adiposity and fat oxidation under diminished insulin action

H Zhou, Y Yamada, K Tsukiyama, K Miyawaki… - Biochemical and …, 2005 - Elsevier
Gut hormone gastric inhibitory polypeptide (GIP) stimulates insulin secretion from pancreatic
β-cells upon ingestion of nutrients. Inhibition of GIP signaling prevents the onset of obesity …

[HTML][HTML] Physiological roles of the GIP receptor in murine brown adipose tissue

JL Beaudry, KD Kaur, EM Varin, LL Baggio, X Cao… - Molecular …, 2019 - Elsevier
Objective Glucose-dependent insulinotropic polypeptide (GIP) is secreted from the gut in
response to nutrient ingestion and promotes meal-dependent insulin secretion and lipid …

GIP receptor deletion in mice confers resistance to high-fat diet-induced obesity via alterations in energy expenditure and adipose tissue lipid metabolism

GA Boer, SN Keenan, PM Miotto… - American Journal of …, 2021 - journals.physiology.org
Glucose-dependent insulinotropic polypeptide (GIP) is best known as an incretin hormone
that is secreted from K-cells of the proximal intestine, but evidence also implicates a role for …

Gastric inhibitory polypeptide receptor antagonism suppresses intramuscular adipose tissue accumulation and ameliorates sarcopenia

Y Takahashi, H Fujita, Y Seino, S Hattori… - Journal of Cachexia …, 2023 - Wiley Online Library
Background Intramuscular adipose tissue (IMAT) formation derived from muscle fibro‐
adipogenic progenitors (FAPs) has been recognized as a pathological feature of …

[HTML][HTML] Chemical gastric inhibitory polypeptide receptor antagonism protects against obesity, insulin resistance, glucose intolerance and associated disturbances in …

VA Gault, PL McClean, RS Cassidy, N Irwin, PR Flatt - Diabetologia, 2007 - Springer
Aims/hypothesis Gastric inhibitory polypeptide (GIP) receptor antagonism with (Pro 3) GIP
improves glucose tolerance and ameliorates insulin resistance and abnormalities of islet …

GIP receptor antagonism reverses obesity, insulin resistance, and associated metabolic disturbances induced in mice by prolonged consumption of high-fat diet

PL McClean, N Irwin, RS Cassidy… - American Journal …, 2007 - journals.physiology.org
The gut hormone gastric inhibitory polypeptide (GIP) plays a key role in glucose
homeostasis and lipid metabolism. This study investigated the effects of administration of a …

Genetic inactivation of GIP signaling reverses aging-associated insulin resistance through body composition changes

C Yamada, Y Yamada, K Tsukiyama, K Yamada… - Biochemical and …, 2007 - Elsevier
Aging is associated with increased fat mass and decreased lean mass, which is strongly
associated with the development of insulin resistance. Gastric inhibitory polypeptide (GIP) is …

Anti-obesity effects of GIPR antagonists alone and in combination with GLP-1R agonists in preclinical models

EA Killion, J Wang, J Yie, SDH Shi, D Bates… - Science Translational …, 2018 - science.org
Glucose-dependent insulinotropic polypeptide (GIP) receptor (GIPR) has been identified in
multiple genome-wide association studies (GWAS) as a contributor to obesity, and GIPR …