High-density lipoprotein metabolism: potential therapeutic targets

MH Davidson, PP Toth - The American journal of cardiology, 2007 - Elsevier
It is well recognized that the lowering of low-density lipoprotein (LDL) cholesterol can
substantially reduce coronary artery disease (CAD)–related morbidity and mortality. The …

High-density lipoproteins and cardiovascular disease: 2010 update

K Alwaili, Z Awan, A Alshahrani… - Expert review of …, 2010 - Taylor & Francis
High-density lipoprotein-cholesterol (HDL-C) is a continuous inverse cardiovascular risk
factor. The mechanisms by which HDLs protect against atherosclerosis are multiple. The …

High-density lipoproteins: biology, epidemiology, and clinical management

HY Choi, A Hafiane, A Schwertani, J Genest - Canadian Journal of …, 2017 - Elsevier
High-density lipoproteins (HDLs) have multiple pleiotropic effects against arteriosclerosis.
Most are independent of the cholesterol mass within HDL particles. Yet, HDL cholesterol …

High-density lipoprotein therapeutics and cardiovascular prevention

S Fazio, MRF Linton - Journal of clinical lipidology, 2010 - Elsevier
The field of cardiovascular prevention has long anticipated the evolution of high-density
lipoprotein (HDL) therapy from unproven metabolic tweaking to pillar of risk reduction on par …

High-density lipoprotein (HDL) dysfunction and the future of HDL

S Ertek - Current vascular pharmacology, 2018 - ingentaconnect.com
Although High Density Lipoprotein Cholesterol (HDL-C) levels are inversely proportional to
cardiovascular risk in many studies, recent pharmacological interventional studies with HDL …

Should raising high-density lipoprotein cholesterol be a matter of debate?

VG Athyros, N Katsiki, A Karagiannis… - Journal of …, 2012 - journals.lww.com
High-density lipoprotein cholesterol (HDL-C) has been identified as an independent inverse
predictor of coronary heart disease, leading to the inclusion of HDL-C in certain risk engines …

Why targeting HDL should work as a therapeutic tool, but has not

MG Sorci-Thomas, MJ Thomas - Journal of cardiovascular …, 2013 - journals.lww.com
Atherosclerosis is one of the most common causes of death and disability in the United
States today despite the availability of statins, which reduce hyperlipidemia, a risk factor that …

HDL mimetics infusion and regression of atherosclerosis: is it still considered a valid therapeutic option?

I Karalis, JW Jukema - Current Cardiology Reports, 2018 - Springer
Abstract Purpose of Review This review aims to summarize and discuss the recent findings
in the field of using HDL mimetics for the treatment of patients with coronary artery disease …

Pleiotropic effects of HDL: towards new therapeutic areas for HDL-targeted interventions

SC Gordts, N Singh, I Muthuramu… - Current Molecular …, 2014 - ingentaconnect.com
Plasma levels of high density lipoprotein (HDL) cholesterol levels and of apolipoprotein AI
are inversely correlated with the incidence of coronary heart disease. According to the HDL …

When high is low: raising low levels of high-density lipoprotein cholesterol

PP Toth - Current cardiology reports, 2008 - Springer
Low serum levels of high-density lipoprotein cholesterol (HDL-C) are highly prevalent and
are recognized as an independent risk factor for cardiovascular morbidity (myocardial …