In response to cellular stress or damage, proliferating cells can induce a specific program
that initiates a state of long-term cell-cycle arrest, termed cellular senescence. Accumulation …

Cellular senescence is a state of permanent cell cycle arrest activated in response to
different damaging stimuli. Activation of cellular senescence is a hallmark of various …

Cellular senescence entails a state of an essentially irreversible proliferative arrest in which
cells remain metabolically active and secrete a range of pro-inflammatory and proteolytic …

Cellular senescence is a cell fate triggered in response to stress and is characterized by
stable cell-cycle arrest and a hypersecretory state. It has diverse biological roles, ranging …

Cellular senescence is a physiological mechanism whereby a proliferating cell undergoes a
stable cell cycle arrest upon damage or stress and elicits a secretory phenotype. This highly …

Originally identified as an outcome of continuous culture of primary cells, cellular
senescence has moved beyond the culture dish and is now a bona fide driver of aging and …

Many cellular stresses activate senescence, a persistent hyporeplicative state characterized
in part by expression of the p16 INK4a cell-cycle inhibitor. Senescent cell production occurs …

Cellular senescence, a process that imposes permanent proliferative arrest on cells in
response to various stressors, has emerged as a potentially important contributor to aging …

Senescent cells are present in premalignant lesions and sites of tissue damage and
accumulate in tissues with age. In vivo identification, quantification and characterization of …

Cellular senescence is a permanent state of cell cycle arrest that promotes tissue
remodeling during development and after injury, but can also contribute to the decline of the …