Cellular senescence is a state of irreversibly arrested proliferation, often induced by
genotoxic stress [1]. Senescent cells participate in a variety of physiological and pathological …

Senescent cells are present in premalignant lesions and sites of tissue damage and
accumulate in tissues with age. In vivo identification, quantification and characterization of …

Almost half a century after the first reports describing the limited replicative potential of
primary cells in culture, there is now overwhelming evidence for the existence of “cellular …

Cellular senescence is a state of stable cell cycle arrest associated with macromolecular
alterations and secretion of proinflammatory cytokines and molecules. From their initial …

Cellular senescence is a physiological mechanism whereby a proliferating cell undergoes a
stable cell cycle arrest upon damage or stress and elicits a secretory phenotype. This highly …

Cellular senescence, an integral component of aging and cancer, arises in response to
diverse triggers, including telomere attrition, macromolecular damage and signaling from …

Cellular senescence, first observed and defined through cell culture studies, is a cell fate
associated with essentially permanent cell cycle arrest and that can be triggered by a variety …

Cellular senescence correlates with changes in the transcriptome. To obtain a complete
view on senescence-associated transcription networks and pathways, we assessed by deep …

SnapShot: Cellular Senescence Pathways Page 1 See online version for legends and
references 816 Cell 170, August 10, 2017 © 2017 Elsevier Inc. DOI http://dx.doi.org/10.1016/j.cell.2017.07.049 …

Senescent cells are highly associated with aging and pathological conditions and could be
targeted to slow the aging process. One commonly used marker to examine senescent cells …