Cellular senescence suppresses cancer by irreversibly arresting cell proliferation.
Senescent cells acquire a proinflammatory senescence-associated secretory phenotype …

Senescence is a cell state occurring in vitro and in vivo after successive replication cycles
and/or upon exposition to various stressors. It is characterized by a strong cell cycle arrest …

In normal tissue, cell division is carefully regulated to maintain the correct proliferative
balance. Abnormal cell division underlies many hypoproliferative and hyperproliferative …

A major goal in cancer and aging research is to discriminate the biochemical modifications
that happen locally that could account for the healthiness or malignancy of tissues …

Cellular senescence was first reported in human fibroblasts as a state of stable in vitro
growth arrest following extended culture. Since that initial observation, a variety of other …

Cellular senescence is the state of irreversible cell cycle arrest that can be induced by a
variety of potentially oncogenic stimuli and has therefore long been considered to suppress …

A critical hallmark of aging is cellular senescence, a state of growth arrest and inflammatory
cytokine release in cells, caused by a variety of stresses. Recent work has convincingly …

Aging is the main risk factor for many degenerative diseases and declining health.
Senescent cells are part of the underlying mechanism for time-dependent tissue dysfunction …

Human cells in culture have a limited proliferative capacity. After a period of vigorous
proliferation, the rate of cell division declines and a number of changes occur in the cells …

Cellular senescence is a signal transduction program leading to irreversible cell cycle arrest.
This growth arrest can be triggered by many different mechanisms including recognition by …