Dysregulated microglia are intimately involved in neurodegeneration, including Alzheimer's
disease (AD) pathogenesis, but the mechanisms controlling pathogenic microglial gene …

Neuroinflammation affects the pathobiology of Alzheimer's disease (AD). Notably, β-amyloid
(Aβ) deposition induces microglial activation and the subsequent production of …

The importance of the complement system in Alzheimer's disease (AD) pathogenesis has
been emphasized through recent genome wide association studies. However, the cellular …

Background Microglia are innate immune cells of the brain that perform phagocytic and
inflammatory functions in disease conditions. Transcriptomic studies of acutely-isolated …

The CCAAT/enhancer binding protein delta (CEBPD, C/EBPδ, NF-IL6β) is induced in many
inflammation-related diseases, suggesting that CEBPD and its downstream targets may play …

Background The linkages between neuroinflammation and Alzheimer's disease (AD)
pathogenesis are well established. What is not, however, is how specific immune pathways …

An important component of chronic neurodegenerative diseases is the generation of an
innate inflammatory response within the CNS. Microglial and astroglial cells play a key role …

Neuroinflammation is a pathological hallmark of Alzheimer's disease (AD), and microglia,
the brain's resident phagocyte, are pivotal for the immune response observed in AD …

Microglia transform from homeostatic to disease‐associated‐microglia (DAM) profiles in
neurodegeneration. Within DAM, we recently identified distinct pro‐inflammatory and anti …

Background Microglia and astrocytes respond to homeostatic disturbances with profound
changes of gene expression. This response, known as glial activation or neuroinflammation …