[HTML][HTML] Ubiquitin ligase COP1 suppresses neuroinflammation by degrading c/EBPβ in microglia
Dysregulated microglia are intimately involved in neurodegeneration, including Alzheimer's
disease (AD) pathogenesis, but the mechanisms controlling pathogenic microglial gene …
disease (AD) pathogenesis, but the mechanisms controlling pathogenic microglial gene …
CCL2 affects β-amyloidosis and progressive neurocognitive dysfunction in a mouse model of Alzheimer's disease
T Kiyota, HE Gendelman, RA Weir, EE Higgins… - Neurobiology of …, 2013 - Elsevier
Neuroinflammation affects the pathobiology of Alzheimer's disease (AD). Notably, β-amyloid
(Aβ) deposition induces microglial activation and the subsequent production of …
(Aβ) deposition induces microglial activation and the subsequent production of …
Blockage of CR1 prevents activation of rodent microglia
H Crehan, J Hardy, J Pocock - Neurobiology of disease, 2013 - Elsevier
The importance of the complement system in Alzheimer's disease (AD) pathogenesis has
been emphasized through recent genome wide association studies. However, the cellular …
been emphasized through recent genome wide association studies. However, the cellular …
[HTML][HTML] Quantitative proteomics of acutely-isolated mouse microglia identifies novel immune Alzheimer's disease-related proteins
Background Microglia are innate immune cells of the brain that perform phagocytic and
inflammatory functions in disease conditions. Transcriptomic studies of acutely-isolated …
inflammatory functions in disease conditions. Transcriptomic studies of acutely-isolated …
CCAAT/enhancer binding protein delta (CEBPD) elevating PTX3 expression inhibits macrophage-mediated phagocytosis of dying neuron cells
CY Ko, LH Chang, YC Lee, E Sterneck, CP Cheng… - Neurobiology of …, 2012 - Elsevier
The CCAAT/enhancer binding protein delta (CEBPD, C/EBPδ, NF-IL6β) is induced in many
inflammation-related diseases, suggesting that CEBPD and its downstream targets may play …
inflammation-related diseases, suggesting that CEBPD and its downstream targets may play …
[HTML][HTML] CCL2 accelerates microglia-mediated Aβ oligomer formation and progression of neurocognitive dysfunction
T Kiyota, M Yamamoto, H Xiong, MP Lambert… - PloS one, 2009 - journals.plos.org
Background The linkages between neuroinflammation and Alzheimer's disease (AD)
pathogenesis are well established. What is not, however, is how specific immune pathways …
pathogenesis are well established. What is not, however, is how specific immune pathways …
Regulation of microglial proliferation during chronic neurodegeneration
D Gómez-Nicola, NL Fransen, S Suzzi… - Journal of …, 2013 - Soc Neuroscience
An important component of chronic neurodegenerative diseases is the generation of an
innate inflammatory response within the CNS. Microglial and astroglial cells play a key role …
innate inflammatory response within the CNS. Microglial and astroglial cells play a key role …
Microglial genes regulating neuroinflammation in the progression of Alzheimer's disease
C Villegas-Llerena, A Phillips… - Current opinion in …, 2016 - Elsevier
Neuroinflammation is a pathological hallmark of Alzheimer's disease (AD), and microglia,
the brain's resident phagocyte, are pivotal for the immune response observed in AD …
the brain's resident phagocyte, are pivotal for the immune response observed in AD …
Transcriptional regulation of homeostatic and disease‐associated‐microglial genes by IRF1, LXRβ, and CEBPα
Microglia transform from homeostatic to disease‐associated‐microglia (DAM) profiles in
neurodegeneration. Within DAM, we recently identified distinct pro‐inflammatory and anti …
neurodegeneration. Within DAM, we recently identified distinct pro‐inflammatory and anti …
[HTML][HTML] Pro-inflammatory gene expression and neurotoxic effects of activated microglia are attenuated by absence of CCAAT/enhancer binding protein β
M Straccia, N Gresa-Arribas, G Dentesano… - Journal of …, 2011 - Springer
Background Microglia and astrocytes respond to homeostatic disturbances with profound
changes of gene expression. This response, known as glial activation or neuroinflammation …
changes of gene expression. This response, known as glial activation or neuroinflammation …