Senescent cells are present in premalignant lesions and sites of tissue damage and
accumulate in tissues with age. In vivo identification, quantification and characterization of …

Aging is the main risk factor for many degenerative diseases and declining health.
Senescent cells are part of the underlying mechanism for time-dependent tissue dysfunction …

Reliable ways to identify senescent cells represent a bottleneck for understanding the roles
of senescence in physiology and disease. This Comment examines the challenges of …

Cellular senescence is a cell fate triggered in response to stress and is characterized by
stable cell-cycle arrest and a hypersecretory state. It has diverse biological roles, ranging …

The influence of the activation of a cellular phenotype termed senescence and it's
importance in ageing and age-related diseases is becoming more and more evident. In fact …

Cellular senescence is a cell state implicated in various physiological processes and a wide
spectrum of age-related diseases. Recently, interest in therapeutically targeting senescence …

Cellular senescence is a permanent state of cell cycle arrest that promotes tissue
remodeling during development and after injury, but can also contribute to the decline of the …

The development of genetic tools allowed for the validation of the pro-aging and pro-disease
functions of senescent cells in vivo. These discoveries prompted the development of …

Given the heterogeneity of senescent cells, our knowledge of both the drivers and
consequences of cellular senescence in tissues and organs remains limited, as is our …

An increase in life expectancy in developed countries has led to a surge of chronic aging-
related diseases. In the last few decades, several studies have provided evidence of the …