In a large proportion of individuals nervous system damage may lead to a debilitating
chronic neuropathic pain. Such pain may now be considered a neuro-immune disorder …

Pain normally subserves a vital role in the survival of the organism, prompting the avoidance
of situations associated with tissue damage. However, the sensation of pain can become …

Inflammatory pain results from the increased excitability of peripheral nociceptive sensory
fibres produced by the action of inflammatory mediators. This excitatory effect, in turn, is a …

It is widely accepted that communication between the nervous and immune systems is
involved in the development of chronic pain. At each level of the nervous system, immune …

There is burgeoning interest in the interaction between the immune and nervous systems.
Pain is mediated by primary sensory neurons (nociceptors) that can respond to a variety of …

Chronic pain can occur after peripheral nerve injury, infection, or inflammation. Under such
neuropathic pain conditions, sensory processing in the affected body region becomes …

Neuropathic pain can have a major effect on quality of life but current therapies are often
inadequate. Growing evidence suggests that neuropathic pain induced by nerve damage is …

The neuromatrix theory of pain proposes that pain is a multidimensional experience
produced by characteristic “neurosignature” patterns of nerve impulses generated by a …

Tissue injury and inflammation result in release of various mediators that promote ongoing
pain or pain hypersensitivity against mechanical, thermal and chemical stimuli. Pro …

Tumor necrosis factor alpha (TNF-α) was discovered more than a century ago, and its known
roles have extended from within the immune system to include a neuro-inflammatory domain …