Traumatic brain injury (TBI) is the leading cause of death in children and adolescents in
developed countries, but there are no blood-based biomarkers to support the diagnosis or …

Osteopontin (OPN) is a matricellular protein that mediates various physiological functions
and is implicated in neuroinflammation, myelination, and perinatal brain injury. However, its …

Blood based traumatic brain injury (TBI) biomarkers offer additional diagnostic, therapeutic,
and prognostic utility. While adult studies are robust, the pediatric population is less well …

Acute brain injury is the leading cause of human death and disability worldwide, which
includes intracerebral haemorrhage, subarachnoid haemorrhage, cerebral ischaemia …

Background Osteopontin (OPN) is a highly phosphorylated sialoprotein and a soluble
cytokine that is widely expressed in a variety of tissues, including the brain. OPN and OPN …

Clinical management of neonatal hypoxic-ischemic encephalopathy (HIE) suffers from the
lack of reliable surrogate marker tests. Proteomic analysis may identify such biomarkers in …

Sepsis is a life-threatening organ dysfunction caused by a dysregulated host-response to
infections. Osteopontin (OPN) is an extracellular matrix protein involved in the inflammatory …

Osteopontin (OPN) is a multifunctional protein which has shown neuroprotective properties
in animal models of cerebral ischemia. Nevertheless, its role in acute human stroke has not …

Objectives: Osteopontin (OPN) is an inflammatory cytokine inducer involved in cell
proliferation and migration in inflammatory diseases or tumors. To investigate the function of …

Background After an acute ischaemic stroke (AIS), several inflammatory biomarkers have
been investigated, but their predictive role on functional recovery remains to be validated …