Osmogen‐Mediated One‐Step Technique of Fabricating Hollow Microparticles for Encapsulation and Delivery of Bioactive Molecules

S Kharel, WL Lee, XY Lee… - Macromolecular …, 2017 - Wiley Online Library
Microparticulate systems composed of biodegradable polymers, such as poly (d, l‐lactic‐co‐
glycolic acid)(PLGA), are widely used for controlled release of bioactive molecules …

Protein bioactivity and polymer orientation is affected by stabilizer incorporation for double-walled microspheres

LE Kokai, H Tan, S Jhunjhunwala, SR Little… - Journal of Controlled …, 2010 - Elsevier
Double-walled microspheres present an improved drug delivery technique for sustained
release of encapsulated substrates. In this study, the release kinetics and biological activity …

Recent advance in polymer based microspheric systems for controlled protein and peptide delivery

Y Yang, Q Chen, J Lin, Z Cai, G Liao… - Current medicinal …, 2019 - ingentaconnect.com
Sustained-release systems made by biodegradable polymers for protein and peptide drug
delivery have received considerable attention by academic researchers and major …

Computer modeling assisted design of monodisperse PLGA microspheres with controlled porosity affords zero order release of an encapsulated macromolecule for 3 …

F Kazazi-Hyseni, M Landin, A Lathuile… - Pharmaceutical …, 2014 - Springer
Purpose The aim of this study was the development of poly (D, L-lactide-co-
glycolide)(PLGA) microspheres with controlled porosity, to obtain microspheres that afford …

Controlled protein release from monodisperse biodegradable double-wall microspheres of controllable shell thickness

Y Xia, PF Ribeiro, DW Pack - Journal of controlled release, 2013 - Elsevier
Biodegradable polymer microparticles are promising delivery depots for protein therapeutics
due to their relatively simple fabrication and facile administration. Double-wall microspheres …

[HTML][HTML] Uniform biodegradable microparticle systems for controlled release

Y Xia, DW Pack - Journal of controlled release: official journal of the …, 2002 - ncbi.nlm.nih.gov
Drug delivery methods can impact efficacy as much as the nature of the drug itself.
Microparticles made of biodegradable polymers such as poly (D, L-lactide-co-glycolide) and …

Changing the pH of the external aqueous phase may modulate protein entrapment and delivery from poly (lactide-co-glycolide) microspheres prepared by aw/o/w …

E Leo, S Pecquet, J Rojas, P Couvreur… - Journal of …, 1998 - Taylor & Francis
The milk model protein, β lactoglobulin (BLG), was encapsulated into micro-spheres
prepared by a multiple emulsion/solvent evaporation method. The effect of the pH of the …

Strategies for encapsulation of small hydrophilic and amphiphilic drugs in PLGA microspheres: state-of-the-art and challenges

F Ramazani, W Chen, CF van Nostrum, G Storm… - International journal of …, 2016 - Elsevier
Abstract Poly (lactide-co-glycolide)(PLGA) microspheres are efficient delivery systems for
controlled release of low molecular weight drugs as well as therapeutic macromolecules …

Optimization of the encapsulation and release of β-lactoglobulin entrapped poly (DL-lactide-co-glycolide) microspheres

J Rojas, H Pinto-Alphandary, E Leo, S Pecquet… - International journal of …, 1999 - Elsevier
The goal of the present paper was to optimize the encapsulation of β-lactoglobulin (BLG)
within poly (lactide-co-glycolide)(PLGA) microparticles prepared by the multiple emulsion …

Feeding liquid, non-ionic surfactant and cyclodextrin affect the properties of insulin-loaded poly (lactide-co-glycolide) microspheres prepared by spray-drying

F Quaglia, G De Rosa, E Granata, F Ungaro… - Journal of controlled …, 2003 - Elsevier
The potential of spray-drying technique for the encapsulation in poly (lactide-co-
glycolide)(PLGA) microspheres of bovine insulin, a poorly stable peptide, has been …