Background Chronic obstructive pulmonary disease (COPD) exacerbations are
heterogenous and profoundly impact the disease trajectory. Bioactive lipid lysophosphatidic …

Lysophospholipids are bioactive signaling molecules derived from cell membrane
glycerophospholipids or sphingolipids and are highly regulated under normal physiological …

Idiopathic pulmonary fibrosis (IPF) is a progressive disease with significant mortality.
Prognostic biomarkers to identify rapid progressors are urgently needed to improve patient …

Background The precise role of lysophospholipids (LysoPLs) in the pathogenesis of acute
exacerbations of Chronic Obstructive Pulmonary Disease (AECOPD) remains unclear. In …

Results: Plasma LPA 18: 0 levels in asthmatics was significantly higher than in normal
healthy subjects (295 nM vs 161 nM±SD 33.5 nM;= p 0.03, students t-test;= 0.0483 two sided …

Purpose Asthma is a chronic inflammatory disease of the airways, and is associated with
upregulation of phospholipase A2 (PLA2), the enzyme that hydrolyzes phosphatidylcholine …

Background Increasing evidence indicates that bioactive lipid mediators are involved in
chronic obstructive pulmonary disease (COPD) pathogenesis. Recently, glycero …

Chronic obstructive pulmonary disease (COPD) is a heterogeneous lung condition
characterized by persistent respiratory symptoms and airflow limitation. While there are …

Background Idiopathic pulmonary fibrosis (IPF) is a progressive and fatal disease with no
effective medical therapies. Recent research has focused on identifying the biological …

Background Lysophosphatidic acid (LPA) is a biologically active lysophospholipid and a
component of normal plasma. LPA binds to receptors expressed on circulating and structural …