Lysophosphatidic acid species are associated with exacerbation in chronic obstructive pulmonary disease
Q Li, W Wong, A Birnberg, A Chakrabarti, X Yang… - BMC Pulmonary …, 2021 - Springer
Background Chronic obstructive pulmonary disease (COPD) exacerbations are
heterogenous and profoundly impact the disease trajectory. Bioactive lipid lysophosphatidic …
heterogenous and profoundly impact the disease trajectory. Bioactive lipid lysophosphatidic …
Serum Lysophosphatidic Acid Measurement by Liquid Chromatography–Mass Spectrometry in COPD Patients
Q Li, WR Wong, A Chakrabarti, A Birnberg… - Journal of the …, 2021 - ACS Publications
Lysophospholipids are bioactive signaling molecules derived from cell membrane
glycerophospholipids or sphingolipids and are highly regulated under normal physiological …
glycerophospholipids or sphingolipids and are highly regulated under normal physiological …
Bioactive lipid lysophosphatidic acid species are associated with disease progression in idiopathic pulmonary fibrosis
Idiopathic pulmonary fibrosis (IPF) is a progressive disease with significant mortality.
Prognostic biomarkers to identify rapid progressors are urgently needed to improve patient …
Prognostic biomarkers to identify rapid progressors are urgently needed to improve patient …
Comparative analysis of lysophospholipid metabolism profiles and clinical characteristics in patients with high vs. low C-reactive protein levels in acute exacerbations …
Q Zhou, C Chang, Y Wang, X Gai, Y Chen, X Gao… - Clinica Chimica …, 2024 - Elsevier
Background The precise role of lysophospholipids (LysoPLs) in the pathogenesis of acute
exacerbations of Chronic Obstructive Pulmonary Disease (AECOPD) remains unclear. In …
exacerbations of Chronic Obstructive Pulmonary Disease (AECOPD) remains unclear. In …
Semi-quantitative analysis of plasma lysophosphatidic acid levels in patients with and without asthma
RF Duff, R Block, A Friedman, H Su… - … HUMAN STUDIES OF …, 2010 - atsjournals.org
Results: Plasma LPA 18: 0 levels in asthmatics was significantly higher than in normal
healthy subjects (295 nM vs 161 nM±SD 33.5 nM;= p 0.03, students t-test;= 0.0483 two sided …
healthy subjects (295 nM vs 161 nM±SD 33.5 nM;= p 0.03, students t-test;= 0.0483 two sided …
Bioactive lysophosphatidylcholine 16: 0 and 18: 0 are elevated in lungs of asthmatic subjects
M Yoder, Y Zhuge, Y Yuan, O Holian… - Allergy, asthma & …, 2014 - synapse.koreamed.org
Purpose Asthma is a chronic inflammatory disease of the airways, and is associated with
upregulation of phospholipase A2 (PLA2), the enzyme that hydrolyzes phosphatidylcholine …
upregulation of phospholipase A2 (PLA2), the enzyme that hydrolyzes phosphatidylcholine …
Understanding the modulations of glycero-lysophospholipids in an elastase-induced murine emphysema model
H Isago, B Uranbileg, A Mitani, M Kurano - Biochemical and Biophysical …, 2024 - Elsevier
Background Increasing evidence indicates that bioactive lipid mediators are involved in
chronic obstructive pulmonary disease (COPD) pathogenesis. Recently, glycero …
chronic obstructive pulmonary disease (COPD) pathogenesis. Recently, glycero …
The Role of Lysophospholipid Metabolites LPC and LPA in the Pathogenesis of Chronic Obstructive Pulmonary Disease
Q Zhou, Y Chen, Y Liang, Y Sun - Metabolites, 2024 - mdpi.com
Chronic obstructive pulmonary disease (COPD) is a heterogeneous lung condition
characterized by persistent respiratory symptoms and airflow limitation. While there are …
characterized by persistent respiratory symptoms and airflow limitation. While there are …
Docosatetraenoyl LPA is elevated in exhaled breath condensate in idiopathic pulmonary fibrosis
SB Montesi, SK Mathai, LN Brenner… - BMC Pulmonary …, 2014 - Springer
Background Idiopathic pulmonary fibrosis (IPF) is a progressive and fatal disease with no
effective medical therapies. Recent research has focused on identifying the biological …
effective medical therapies. Recent research has focused on identifying the biological …
Lysophosphatidic acid is detectable in human bronchoalveolar lavage fluids at baseline and increased after segmental allergen challenge
SN Georas, E Berdyshev, W Hubbard… - Clinical & …, 2007 - Wiley Online Library
Background Lysophosphatidic acid (LPA) is a biologically active lysophospholipid and a
component of normal plasma. LPA binds to receptors expressed on circulating and structural …
component of normal plasma. LPA binds to receptors expressed on circulating and structural …