Background While pure mesenchymal stem cell (MSC) treatment for spinal cord injury (SCI)
is known to be safe, its efficacy is insufficient. Therefore, gene-modified stem cells are being …

Objective Through our previous clinical trials, the demonstrated therapeutic effects of MSC in
chronic spinal cord injury (SCI) were found to be not sufficient. Therefore, the need to …

Background Axonal regeneration is a prerequisite for recovery from spinal cord injury. Here,
we investigated whether Wnt3a-secreting fibroblasts exert a favorable effect on spinal cord …

Numerous studies have shown the benefits of mesenchymal stem cells (MSCs) on the repair
of spinal cord injury (SCI) model and on behavioral improvement, but the underlying …

Introduction Severe spinal cord injury often causes temporary or permanent damages in
strength, sensation, or autonomic functions below the site of the injury. So far, there is still no …

Objective: To explore the repair effect of Wnt3a on injured spinal cord in rats. Methods:
Moderate spinal cord contusion injury was made in 40 adult Sprague–Dawley rats at T10 …

Purpose: Despite substantial advances in surgical care and rehabilitation, the
consequences of spinal cord injury (SCI) continue to present major challenges. Here we …

Genetic engineering of mesenchymal stem cells (MSCs) and neuronal stem cells (NSCs)
has been used to treat spinal cord injuries (SCI). As a mechanism of therapy, MSCs secrete …

Spinal cord injury (SCI) is caused by an external force, leading to severe dysfunction of the
limbs below the injured segment. The inflammatory response plays a vital role in the …

Multiple types of stem cells have been proposed for the treatment of spinal cord injury, but
their comparative information remains elusive. In this study, a rat model of T10 contusion …