Emerging technologies and platforms for the immunodetection of multiple biochemical markers in osteoarthritis research and therapy

E Bernotiene, E Bagdonas, G Kirdaite… - Frontiers in …, 2020 - frontiersin.org
Biomarkers, especially biochemical markers, are important in osteoarthritis (OA) research,
clinical trials, and drug development and have potential for more extensive use in …

[HTML][HTML] Application of biomarkers in the development of drugs intended for the treatment of osteoarthritis

VB Kraus, B Burnett, J Coindreau, S Cottrell… - Osteoarthritis and …, 2011 - Elsevier
OBJECTIVE: Osteoarthritis (OA) is a chronic and slowly progressive disease for which
biomarkers may be able to provide a more rapid indication of therapeutic responses to …

The evolving role of biomarkers for osteoarthritis

M Ishijima, H Kaneko, K Kaneko - Therapeutic advances in …, 2014 - journals.sagepub.com
Osteoarthritis (OA) is an increasingly important public health concern as the prevalence of
this disease becomes higher and higher due to the ageing population. However, in addition …

Recent progress toward biomarker identification in osteoarthritis

F De Ceuninck, M Sabatini, P Pastoureau - Drug discovery today, 2011 - Elsevier
Osteoarthritis (OA), the most common and disabling form of arthritic disease, is characterized
by a slow and progressive degeneration of articular cartilage. Its etiology is multifactorial and …

Biomarkers: in combination they may do better

FMK Williams - Arthritis research & therapy, 2009 - Springer
The field of biomarkers is a growing one, particularly in osteoarthritis (OA). OA is the most
common disabling condition in older persons and a major cause of morbidity. While the …

Molecular taxonomy of osteoarthritis for patient stratification, disease management and drug development: biochemical markers associated with emerging clinical …

A Mobasheri, WE van Spil, E Budd… - Current opinion in …, 2019 - journals.lww.com
In this review, we have focused on the molecular biomarkers of four distinct osteoarthritis
subtypes including inflammatory, subchondral bone remodelling, metabolic syndrome and …

[HTML][HTML] Defining the osteoarthritis patient: back to the future

GP Dobson, HL Letson, A Grant, P McEwen… - Osteoarthritis and …, 2018 - Elsevier
The history of osteoarthritis (OA) is important because it can help broaden our perspective
on past and present controversies. The naming of OA, beginning with Heberden's nodes, is …

Review of soluble biomarkers of osteoarthritis: lessons from animal models

CB Legrand, CJ Lambert, FV Comblain… - Cartilage, 2017 - journals.sagepub.com
Objective Osteoarthritis (OA) is one of the leading causes of disability within the adult
population. Currently, its diagnosis is mainly based on clinical examination and standard …

inflammation and biomarkers in osteoarthritis

A Mobasheri, JE Fonseca, O Gualillo, Y Henrotin… - Frontiers in …, 2021 - frontiersin.org
Osteoarthritis (OA) is the most common form of arthritis affecting more than 500 million
people globally (1). It accounts for more pain and functional disability than any other …

Biomarkers of osteoarthritis—a narrative review on causal links with metabolic syndrome

SJ Lynskey, MJ Macaluso, SD Gill, SL McGee… - Life, 2023 - mdpi.com
Development of OA (OA) is multifactorial and is strongly associated with risk factors such as
aging, trauma, metabolic disorders, and obesity. Metabolic Syndrome (MetS)-associated OA …