Objective: Additional treatments for therapeutic hypothermia are required to maximize
neuroprotection for perinatal asphyxial encephalopathy. We assessed neuroprotective …

Cooling to 33.5° C in babies with neonatal encephalopathy significantly reduces death and
disability, however additional therapies are needed to maximize brain protection. Following …

Background Moderate cooling after birth asphyxia is associated with substantial reductions
in death and disability, but additional therapies might provide further benefit. We assessed …

Perinatal asphyxia can result in neuronal injury with long‐term neurological and behavioral
consequences. Although hypothermia may provide some modest benefit, the intervention …

Background Therapeutic hypothermia (TH) is standard treatment following perinatal
asphyxia in newborn infants. Experimentally, TH is neuroprotective after moderate hypoxia …

Background Neuroprotection from therapeutic hypothermia (HT) is incomplete, therefore
additional strategies are necessary to improve long-term outcomes. We assessed the …

Perinatal hypoxia-ischemia is a major cause of neonatal morbidity. It generates primary
neuronal damage of the neonatal brain and later secondary damage when reperfusion of …

Hypothermia is ineffective in 45% of neonates with hypoxic-ischemic encephalopathy.
Xenon has additive neuroprotective properties, but is expensive, and its application …

Hypothermia (HT) improves outcome after neonatal hypoxia–ischemia. Combination therapy
may extend neuroprotection. The noble anesthetic gas xenon (Xe) has an excellent safety …

Hypoxic ischaemic encephalopathy continues to be a significant cause of death and
disability worldwide. In the last 1–2years, therapeutic hypothermia has entered clinical …