Mitochondria are associated with various cellular activities critical to homeostasis,
particularly in the nervous system. The plastic architecture of the mitochondrial network and …

Significance: The mitochondrial energy-transducing capacity is essential for the
maintenance of neuronal function, and the impairment of energy metabolism and redox …

Neurodegenerative diseases are a heterogeneous group of disorders that are incurable and
characterized by the progressive degeneration of the function and structure of the central …

Mitochondria are bilayer sub-cellular organelles that are an integral part of normal cellular
physiology. They are responsible for producing the majority of a cell's ATP, thus supplying …

The view of mitochondria acting solely as a powerhouse of the cell is no longer accurate.
Besides cell bioenergetics, primary targets of mitochondrial studies include their interplay …

Mitochondria are dynamic cellular organelles that consistently migrate, fuse, and divide to
modulate their number, size, and shape. In addition, they produce ATP, reactive oxygen …

The human brain is a highly complex organ with remarkable energy demands. Although it
represents only 2% of the total body weight, it accounts for 20% of all oxygen consumption …

Neurodegeneration in mitochondrial disorders is considered irreversible because of limited
metabolic plasticity in neurons, yet the cell-autonomous implications of mitochondrial …

Mitochondrial dysfunction entailing decreased energy‐transducing capacity and perturbed
redox homeostasis is an early and sometimes initiating event in ageing and age‐related …

Age is the main risk factor for a number of human diseases, including neurodegenerative
disorders such as Alzheimer's disease, Parkinson's disease, and amyotrophic lateral …