Sepsis, a disease of divergent pro-and anti-inflammatory–mediated pathways, has a high
prevalence of morbidity and mortality, yet an understanding of potential unifying mediators …

Targeted IL-10 therapy improves survival in preclinical models of critical illness, and
intestine-specific IL-10 decreases inflammation in models of chronic inflammatory disease …

Interleukin-10 is the most potent anti-inflammatory cytokine yet identified. It has multiple
actions affecting the innate immune system as well as humoral and cellular immune …

Sepsis is a worldwide health priority characterized by the occurrence of severe
immunosuppression associated with increased risk of death and secondary infections …

Abstract Interleukin (IL)-10 is a pleiotropic cytokine produced by both T cells and
macrophages and possesses both anti-inflammatory and immunosuppressive properties. IL …

Sepsis is a syndrome involving systemic inflammation as well as an infectious focus.
Accordingly, the host immune response to sepsis involves complex leukocyte interplay that …

Interleukin 10 (IL-10) is known to suppress the induction of proinflammatory cytokines such
as tumor necrosis factor (TNF) and IL-1 and is itself induced by monocytes and …

Abstract Interleukin 10 (IL-10), a cytokine with inhibitory activity on inflammation and cell-
mediated immune responses, holds enormous potential for the treatment of inflammatory …

Interleukin 15 is essential for the development and differentiation of NK and memory
CD8+(mCD8+) T cells. Our laboratory previously showed that NK and CD8+ T lymphocytes …

To determine the role of endogenous IL-10 in local antibacterial host defense and in the
development of a systemic inflammatory response syndrome during abdominal sepsis, IL-10 …