New targeted therapies for treatment of thrombosis in antiphospholipid syndrome

SS Pierangeli, ME Vega-Ostertag… - Expert reviews in …, 2007 - cambridge.org
Antiphospholipid (aPL) antibodies (Abs) are associated with thrombosis and pregnancy loss
in antiphospholipid syndrome (APS), a disorder initially characterised in patients with …

Antiphospholipid syndrome: pathogenesis and a window of treatment opportunities in the future

AA Mehdi, I Uthman… - European journal of clinical …, 2010 - Wiley Online Library
Eur J Clin Invest 2010; 40 (5): 451–464 Abstract Background Antiphospholipid syndrome
(APS) is a systemic autoimmune vascular disease characterized by recurrent thrombotic …

Pathophysiology of thrombosis and potential targeted therapies in antiphospholipid syndrome

O Amengual, T Atsumi, T Koike - Current Vascular …, 2011 - ingentaconnect.com
The antiphospholipid syndrome (APS) is an autoimmune disease in which recurrent
vascular thrombosis, pregnancy morbidity or a combination of these events is associated …

Current status and future prospects for the treatment of antiphospholipid syndrome

A Al Marzooqi, A Leone, J Al Saleh… - Expert Review of …, 2016 - Taylor & Francis
Antiphospholipid syndrome (APS) is a prothrombotic disease characterized by thrombosis
and pregnancy morbidity in the presence of antiphospholipid antibodies (apL). Management …

Treatment of thrombotic antiphospholipid syndrome: the rationale of current management—an insight into future approaches

CB Chighizola, T Ubiali… - Journal of Immunology …, 2015 - Wiley Online Library
Vascular thrombosis and pregnancy morbidity represent the clinical manifestations of
antiphospholipid syndrome (APS), which is serologically characterized by the persistent …

Antiphospholipid antibody-mediated thrombotic mechanisms in antiphospholipid syndrome: towards pathophysiology-based treatment

A Islam, F Alam, T Haryo Sasongko… - Current …, 2016 - ingentaconnect.com
Antiphospholipid syndrome (APS) is a systemic autoimmune disease characterized by a
persistently high titer of antiphospholipid antibodies (aPLs). In addition to pregnancy …

Mechanisms of aPL-mediated thrombosis: effects of aPL on endothelium and platelets

ME Vega-Ostertag, SS Pierangeli - Current rheumatology reports, 2007 - Springer
Antiphospholipid antibodies (aPL) are associated with thrombosis and pregnancy loss in
patients with systemic lupus erythematosus and antiphospholipid syndrome. Strong …

[HTML][HTML] Pathogenic role of complement in antiphospholipid syndrome and therapeutic implications

F Tedesco, MO Borghi, M Gerosa… - Frontiers in …, 2018 - frontiersin.org
Antiphospholipid syndrome (APS) is an acquired autoimmune disease characterized by
thromboembolic events, pregnancy morbidity, and the presence of antiphospholipid (aPL) …

Antiphospholipid syndrome: from pathogenesis to novel immunomodulatory therapies

C Comarmond, P Cacoub - Autoimmunity Reviews, 2013 - Elsevier
Antiphospholipid syndrome (APS) is characterized by recurrent thrombosis and pregnancy
morbidity in association with the persistent presence of circulating antiphospholipid …

New therapeutic targets for the antiphospholipid syndrome

C Pericleous, Y Ioannou - Expert opinion on therapeutic targets, 2010 - Taylor & Francis
Importance of the field: The antiphospholipid syndrome (APS) is an autoimmune condition
whereby pathogenic antiphospholipid antibodies (aPL) cause vascular thrombosis and/or …