Understanding the role of tryptophan and serotonin metabolism in gastrointestinal function
D Keszthelyi, FJ Troost… - Neurogastroenterology & …, 2009 - Wiley Online Library
Tryptophan is the precursor of a wide array of metabolites, which are involved in a variety of
aspects of human nutrition and metabolism. Accumulating evidence suggests a role of …
aspects of human nutrition and metabolism. Accumulating evidence suggests a role of …
Tryptophan availability for kynurenine pathway metabolism across the life span: control mechanisms and focus on aging, exercise, diet and nutritional supplements
AAB Badawy - Neuropharmacology, 2017 - Elsevier
Tryptophan (Trp) availability for the kynurenine pathway (KP) across the life span is
discussed. Free (non-albumin-bound) plasma Trp is the major determinant of the flux of Trp …
discussed. Free (non-albumin-bound) plasma Trp is the major determinant of the flux of Trp …
[HTML][HTML] Monitoring the kynurenine system: Concentrations, ratios or what else?
The tryptophan-kynurenine metabolic pathway plays the most essential role in tryptophan
metabolism, producing various endogenous bioactive molecules. The activation of the …
metabolism, producing various endogenous bioactive molecules. The activation of the …
The kynurenine pathway in neurodegenerative diseases: mechanistic and therapeutic considerations
L Tan, JT Yu, L Tan - Journal of the neurological sciences, 2012 - Elsevier
The kynurenine pathway (KP), the primary route of tryptophan degradation in mammalian
cells, consists of many metabolites including kynurenic acid (KYNA), quinolinic acid (QUIN) …
cells, consists of many metabolites including kynurenic acid (KYNA), quinolinic acid (QUIN) …
Crosstalk between tryptophan metabolism via kynurenine pathway and carbohydrate metabolism in the context of cardio-metabolic risk
M Kiluk, J Lewkowicz, D Pawlak… - Journal of Clinical …, 2021 - mdpi.com
Scientific interest in tryptophan metabolism via the kynurenine pathway (KP) has increased
in the last decades. Describing its metabolites helped to increase their roles in many …
in the last decades. Describing its metabolites helped to increase their roles in many …
Host and gut microbial tryptophan metabolism and type 2 diabetes: an integrative analysis of host genetics, diet, gut microbiome and circulating metabolites in cohort …
Objective Tryptophan can be catabolised to various metabolites through host kynurenine
and microbial indole pathways. We aimed to examine relationships of host and microbial …
and microbial indole pathways. We aimed to examine relationships of host and microbial …
Central kynurenine pathway shift with age in women
J De Bie, J Guest, GJ Guillemin… - Journal of …, 2016 - Wiley Online Library
Age is considered a dominant risk factor in the development of most neurodegenerative
disorders. The kynurenine pathway, a major metabolic pathway of tryptophan is altered in …
disorders. The kynurenine pathway, a major metabolic pathway of tryptophan is altered in …
Tryptophan metabolites in depression: Modulation by gut microbiota
Clinical depression is a multifactorial disorder and one of the leading causes of disability
worldwide. The alterations in tryptophan metabolism such as changes in the levels of …
worldwide. The alterations in tryptophan metabolism such as changes in the levels of …
[HTML][HTML] Alteration of fecal tryptophan metabolism correlates with shifted microbiota and may be involved in pathogenesis of colorectal cancer
XZ Sun, DY Zhao, YC Zhou, QQ Wang… - World Journal of …, 2020 - ncbi.nlm.nih.gov
BACKGROUND Gut tryptophan (Trp) metabolites are produced by microbiota and/or host
metabolism. Some of them have been proven to promote or inhibit colorectal cancer (CRC) …
metabolism. Some of them have been proven to promote or inhibit colorectal cancer (CRC) …
Kynurenine and its metabolites in Alzheimer's disease patients
E Gulaj, K Pawlak, B Bien, D Pawlak - Advances in medical sciences, 2010 - Elsevier
Purpose The kynurenine pathway (KP) is a major route of tryptophan metabolism. Several
metabolites of this pathway are proposed to be involved in the pathogenesis of Alzheimer's …
metabolites of this pathway are proposed to be involved in the pathogenesis of Alzheimer's …