Tryptophan is the precursor of a wide array of metabolites, which are involved in a variety of
aspects of human nutrition and metabolism. Accumulating evidence suggests a role of …

Tryptophan (Trp) availability for the kynurenine pathway (KP) across the life span is
discussed. Free (non-albumin-bound) plasma Trp is the major determinant of the flux of Trp …

The tryptophan-kynurenine metabolic pathway plays the most essential role in tryptophan
metabolism, producing various endogenous bioactive molecules. The activation of the …

The kynurenine pathway (KP), the primary route of tryptophan degradation in mammalian
cells, consists of many metabolites including kynurenic acid (KYNA), quinolinic acid (QUIN) …

Scientific interest in tryptophan metabolism via the kynurenine pathway (KP) has increased
in the last decades. Describing its metabolites helped to increase their roles in many …

Objective Tryptophan can be catabolised to various metabolites through host kynurenine
and microbial indole pathways. We aimed to examine relationships of host and microbial …

Age is considered a dominant risk factor in the development of most neurodegenerative
disorders. The kynurenine pathway, a major metabolic pathway of tryptophan is altered in …

Clinical depression is a multifactorial disorder and one of the leading causes of disability
worldwide. The alterations in tryptophan metabolism such as changes in the levels of …

BACKGROUND Gut tryptophan (Trp) metabolites are produced by microbiota and/or host
metabolism. Some of them have been proven to promote or inhibit colorectal cancer (CRC) …

Purpose The kynurenine pathway (KP) is a major route of tryptophan metabolism. Several
metabolites of this pathway are proposed to be involved in the pathogenesis of Alzheimer's …