Nuclear receptors are ligand-activated transcription factors that regulate gene expression of
a variety of key molecular signals involved in liver fibrosis. The primary cellular driver of liver …

Liver fibrosis is a major cause of morbidity and mortality worldwide due to chronic viral
hepatitis and, more recently, from fatty liver disease associated with obesity. Hepatic stellate …

Hepatocyte death, inflammation, and liver fibrosis are the hallmarks of chronic liver disease.
Tumor necrosis factor-α (TNFα) is an inflammatory cytokine involved in liver inflammation …

The nuclear receptor superfamily contains important transcriptional regulators that play
pleiotropic roles in cell differentiation, development, proliferation, and metabolic processes …

Nuclear receptors are ligand‐activated transcriptional regulators of several key aspects of
hepatic physiology and pathophysiology. As such, nuclear receptors control a large variety …

Tumor necrosis factor (TNF) has been implicated in the progression of many chronic liver
diseases leading to fibrosis; however, the role of TNF in fibrogenesis is controversial and the …

Hepatic fibrosis is a wound‐healing response to chronic liver injury, which if persistent leads
to cirrhosis and liver failure. Exciting progress has been made in understanding the …

Introduction: Chronic liver injury to hepatocytes or cholangiocytes, when left unmanaged,
leads to the development of liver fibrosis, a condition characterized by the excessive …

There have been considerable recent advances towards a better understanding of the
complex cellular and molecular network underlying liver fibrogenesis. Recent data indicate …

Liver fibrosis is end-stage liver disease that can be rescued. If irritation continues due to viral
infection, schistosomiasis and alcoholism, liver fibrosis can progress to liver cirrhosis and …