Progress in xenotransplantation: overcoming immune barriers

M Sykes, DH Sachs - Nature Reviews Nephrology, 2022 - nature.com
A major limitation of organ allotransplantation is the insufficient supply of donor organs.
Consequently, thousands of patients die every year while waiting for a transplant. Progress …

[HTML][HTML] Progress in xenotransplantation: immunologic barriers, advances in gene editing, and successful tolerance induction strategies in pig-to-primate …

DL Eisenson, Y Hisadome, K Yamada - Frontiers in immunology, 2022 - frontiersin.org
Organ transplantation is the most effective treatment for end stage organ failure, but there
are not enough organs to meet burgeoning demand. One potential solution to this organ …

[HTML][HTML] Xenotransplantation: a new era

AN Carrier, A Verma, M Mohiuddin, M Pascual… - Frontiers in …, 2022 - frontiersin.org
Organ allotransplantation has now reached an impassable ceiling inherent to the limited
supply of human donor organs. In the United States, there are currently over 100,000 …

Physiologic and immunologic hurdles to xenotransplantation

B Samstein, JL Platt - Journal of the American Society of …, 2001 - journals.lww.com
The major problem in the field of renal transplantation is currently the shortage of available
kidneys. However, the use of animals as a source of kidneys, ie, xenotransplantation, is …

Overcoming the barriers to xenotransplantation: prospects for the future

B Ekser, DKC Cooper - Expert review of clinical immunology, 2010 - Taylor & Francis
Cross-species transplantation (xenotransplantation) has immense potential to solve the
critical need for organs, tissues and cells for clinical transplantation. The increasing …

Transplanting organs from pigs to humans

M Sykes, DH Sachs - Science immunology, 2019 - science.org
The success of organ transplantation is limited by the complications of immunosuppression,
by chronic rejection, and by the insufficient organ supply, and thousands of patients die …

Xenotransplantation: back to the future?

RPH Meier, YD Muller, A Balaphas… - Transplant …, 2018 - Wiley Online Library
The field of xenotransplantation has fluctuated between great optimism and doubts over the
last 50 years. The initial clinical attempts were extremely ambitious but faced technical and …

[HTML][HTML] Current status of xenotransplantation research and the strategies for preventing xenograft rejection

Q Zhou, T Li, K Wang, Q Zhang, Z Geng… - Frontiers in …, 2022 - frontiersin.org
Transplantation is often the last resort for end-stage organ failures, eg, kidney, liver, heart,
lung, and pancreas. The shortage of donor organs is the main limiting factor for successful …

Xenoantigen deletion and chemical immunosuppression can prolong renal xenograft survival

AB Adams, SC Kim, GR Martens, JM Ladowski… - Annals of …, 2018 - journals.lww.com
Objective: Xenotransplantation using pig organs could end the donor organ shortage for
transplantation, but humans have xenoreactive antibodies that cause early graft rejection …

[HTML][HTML] Xenotransplantation: current status in preclinical research

T Lu, B Yang, R Wang, C Qin - Frontiers in immunology, 2020 - frontiersin.org
The increasing life expectancy of humans has led to a growing numbers of patients with
chronic diseases and end-stage organ failure. Transplantation is an effective approach for …