Progress in xenotransplantation: overcoming immune barriers
M Sykes, DH Sachs - Nature Reviews Nephrology, 2022 - nature.com
A major limitation of organ allotransplantation is the insufficient supply of donor organs.
Consequently, thousands of patients die every year while waiting for a transplant. Progress …
Consequently, thousands of patients die every year while waiting for a transplant. Progress …
[HTML][HTML] Progress in xenotransplantation: immunologic barriers, advances in gene editing, and successful tolerance induction strategies in pig-to-primate …
DL Eisenson, Y Hisadome, K Yamada - Frontiers in immunology, 2022 - frontiersin.org
Organ transplantation is the most effective treatment for end stage organ failure, but there
are not enough organs to meet burgeoning demand. One potential solution to this organ …
are not enough organs to meet burgeoning demand. One potential solution to this organ …
[HTML][HTML] Xenotransplantation: a new era
AN Carrier, A Verma, M Mohiuddin, M Pascual… - Frontiers in …, 2022 - frontiersin.org
Organ allotransplantation has now reached an impassable ceiling inherent to the limited
supply of human donor organs. In the United States, there are currently over 100,000 …
supply of human donor organs. In the United States, there are currently over 100,000 …
Physiologic and immunologic hurdles to xenotransplantation
B Samstein, JL Platt - Journal of the American Society of …, 2001 - journals.lww.com
The major problem in the field of renal transplantation is currently the shortage of available
kidneys. However, the use of animals as a source of kidneys, ie, xenotransplantation, is …
kidneys. However, the use of animals as a source of kidneys, ie, xenotransplantation, is …
Overcoming the barriers to xenotransplantation: prospects for the future
B Ekser, DKC Cooper - Expert review of clinical immunology, 2010 - Taylor & Francis
Cross-species transplantation (xenotransplantation) has immense potential to solve the
critical need for organs, tissues and cells for clinical transplantation. The increasing …
critical need for organs, tissues and cells for clinical transplantation. The increasing …
Transplanting organs from pigs to humans
M Sykes, DH Sachs - Science immunology, 2019 - science.org
The success of organ transplantation is limited by the complications of immunosuppression,
by chronic rejection, and by the insufficient organ supply, and thousands of patients die …
by chronic rejection, and by the insufficient organ supply, and thousands of patients die …
Xenotransplantation: back to the future?
The field of xenotransplantation has fluctuated between great optimism and doubts over the
last 50 years. The initial clinical attempts were extremely ambitious but faced technical and …
last 50 years. The initial clinical attempts were extremely ambitious but faced technical and …
[HTML][HTML] Current status of xenotransplantation research and the strategies for preventing xenograft rejection
Transplantation is often the last resort for end-stage organ failures, eg, kidney, liver, heart,
lung, and pancreas. The shortage of donor organs is the main limiting factor for successful …
lung, and pancreas. The shortage of donor organs is the main limiting factor for successful …
Xenoantigen deletion and chemical immunosuppression can prolong renal xenograft survival
AB Adams, SC Kim, GR Martens, JM Ladowski… - Annals of …, 2018 - journals.lww.com
Objective: Xenotransplantation using pig organs could end the donor organ shortage for
transplantation, but humans have xenoreactive antibodies that cause early graft rejection …
transplantation, but humans have xenoreactive antibodies that cause early graft rejection …
[HTML][HTML] Xenotransplantation: current status in preclinical research
T Lu, B Yang, R Wang, C Qin - Frontiers in immunology, 2020 - frontiersin.org
The increasing life expectancy of humans has led to a growing numbers of patients with
chronic diseases and end-stage organ failure. Transplantation is an effective approach for …
chronic diseases and end-stage organ failure. Transplantation is an effective approach for …