Epidermal growth factor (EGF) receptor (EGFR) signalling regulates diverse cellular
functions, promoting cell proliferation, differentiation, migration, cell growth and survival …

Ligand activation of the epidermal growth factor receptor (EGFR) leads to its rapid
internalization and eventual delivery to lysosomes. This process is thought to be a …

The canonical description of transmembrane receptor function is initial binding of ligand,
followed by initiation of intracellular signaling and then internalization en route to …

Signaling from the epidermal growth factor receptor (EGFR) elicits multiple biological
responses, including cell proliferation, migration, and survival. Receptor endocytosis and …

The epidermal growth factor receptor (EGFR) has been one of the most intensely studied
cell surface receptors due to its well-established roles in developmental biology, tissue …

The ligand-stimulated epidermal growth factor receptor (EGFR) has been extensively
studied in the analysis of molecular mechanisms regulating endocytic traffic and the role of …

The epidermal growth factor receptor (EGFR) is a long known, versatile signal transducer
that has been well conserved during evolution. It functions in a wide range of cellular …

• Introduction• Endocytosis of EGFR‐Kinase activity‐Clathrin‐coated pits‐Ubiquitination‐
Effects of EGFR‐ErbB2 heterodimerization on EGFR internalization• Cellular and molecular …

Signaling by cell surface receptors appears to be relatively straight-forward: ligand binds to
the extracellular domain of the receptor and biochemical changes are communicated into …

Receptor tyrosine kinases such as the epidermal growth factor receptor (EGFR) elicit
proliferation, migration, and differentiation in a wide spectrum of cell types through various …