Previous studies in several different trigeminal nerve injury/inflammation models indicated
that the hyperexcitability of primary afferent neurons contributes to the pain pathway …

Trigeminal neuropathic pain is the most debilitating pain disorder but current treatments
including opiates are not effective. A common symptom of trigeminal neuropathic pain is …

Voltage-gated K+ (Kv) channels are one of the important physiological regulators of the
membrane potentials in excitable cells, including sensory ganglion neurons. The aim of the …

Background Hyperexcitability of nociceptive afferent fibers is an underlying mechanism of
neuropathic pain and ion channels involved in neuronal excitability are potentially …

Electrical excitation of peripheral somatosensory nerves is a first step in generation of most
pain signals in mammalian nervous system. Such excitation is controlled by an intricate set …

Inflammation suppresses satellite glial inward rectifying K+(Kir) currents in the trigeminal
ganglia. Kir channel may be a potential therapeutic target for treatment of pain. ABSTRACT …

Voltage-gated potassium (Kv) channels are critical in controlling neuronal excitability and
are involved in the induction of neuropathic pain. Therefore, Kv channels might be potential …

Background Trigeminal neuralgia is a disorder of paroxysmal and severely disabling facial
pain and continues to be a real therapeutic challenge. At present there are few effective …

Pathological pain is a hyperexcitability disorder. Since the excitability of a neuron is set and
controlled by a complement of ion channels it expresses, in order to understand and treat …

A-type voltage-gated potassium (Kv) channels are major regulators of neuronal excitability
that have been mainly characterized in the central nervous system. By contrast, there is a …