The changing epidemiology of congenital heart disease

T Van Der Bom, AC Zomer, AH Zwinderman… - Nature Reviews …, 2011 - nature.com
Congenital heart disease is the most common congenital disorder in newborns. Advances in
cardiovascular medicine and surgery have enabled most patients to reach adulthood …

The developing heart and congenital heart defects: a make or break situation

BG Bruneau - Clinical genetics, 2003 - Wiley Online Library
Congenital heart defects are common in humans, but the underlying basis for these defects
is not well understood. It has been clear that abnormal heart development is at the root of …

Genetic causes of syndromic and non-syndromic congenital heart disease

AC Fahed, GM Nemer - Mutations in human genetic disease, 2012 - books.google.com
Congenital heart disease (CHD) is the most common human congenital defect, and a
leading cause of death in infants. With an incidence that varies between 0.8 to 2% in …

Molecular genetics and complex inheritance of congenital heart disease

NS Diab, S Barish, W Dong, S Zhao, G Allington, X Yu… - Genes, 2021 - mdpi.com
Congenital heart disease (CHD) is the most common congenital malformation and the
leading cause of mortality therein. Genetic etiologies contribute to an estimated 90% of CHD …

Cardiac development: new concepts

PJ Gruber - Clinics in perinatology, 2005 - perinatology.theclinics.com
Congenital heart disease (CHD) is a devastating complex of diseases resulting from defects
of development. It affects more than 1 of every 100 live births and is responsible for most …

Genetic basis of human congenital heart disease

SN Nees, WK Chung - Cold Spring Harbor perspectives …, 2020 - cshperspectives.cshlp.org
Congenital heart disease (CHD) is the most common major congenital anomaly with an
incidence of∼ 1% of live births and is a significant cause of birth defect–related mortality …

Genetic Alterations of Transcription Factors and Signaling Molecules Involved in the Development of Congenital Heart Defects—A Narrative Review

AC Bolunduț, C Lazea, CM Mihu - Children, 2023 - mdpi.com
Congenital heart defects (CHD) are the most common congenital abnormality, with an
overall global birth prevalence of 9.41 per 1000 live births. The etiology of CHDs is complex …

Genetics of congenital heart disease

Y Zhao, W Deng, Z Wang, Y Wang, H Zheng, K Zhou… - Clinica Chimica …, 2023 - Elsevier
During embryonic development, the cardiovascular system and the central nervous system
exhibit a coordinated developmental process through intricate interactions. Congenital heart …

Genetic basis of congenital cardiovascular malformations

SR Lalani, JW Belmont - European journal of medical genetics, 2014 - Elsevier
Cardiovascular malformations are a singularly important class of birth defects and due to
dramatic improvements in medical and surgical care, there are now large numbers of adult …

The molecular genetics of congenital heart disease: a review of recent developments

M Wolf, CT Basson - Current Opinion in Cardiology, 2010 - journals.lww.com
The recent developments in the genetics of congenital heart disease are reviewed. In many
cases, it is the novel interactions of previously known genes that highlight this year's …