We have devised a novel approach for producing simian immunodeficiency virus (SIV)
strains and, potentially, human immunodeficiency virus type 1 (HIV-1) strains that are limited …

Lentiviral vectors are attractive candidates for gene therapy because of their ability to
integrate into nondividing cells. To date, conventional HIV-1-based vectors can be produced …

In contrast to oncoviruses, lentiviruses do not require target cell division for integration into
the host genome. Lentiviral vectors can therefore expand the spectrum of target cells …

The safety of lentiviral vectors for clinical applications is still a major concern. The gag-pol
expression plasmids and the lentiviral vectors used in previous studies contain homologous …

Lentivirus vectors based on human immunodeficiency virus (HIV) type 1 (HIV-1) constitute a
recent development in the field of gene therapy. A key property of HIV-1-derived vectors is …

The use of human immunodeficiency virus vectors for gene therapy is hampered by concern
over their safety. This concern might be ameliorated, in part, if the viral accessory genes and …

A nonintegrating mutant, SIVsmD116N, was derived from the infectious pathogenic
SIVsmE543-3 clone by introducing an Asp (D) to Asn (N) mutation into the catalytic domain …

In lentivirus infections, there are typically few cells in the host that harbor the provirus. For
this reason, molecular clones of human and simian immunodeficiency viruses (HIV and SIV) …

Lentiviruses infect both dividing and nondividing cells. In this study we characterized a
lentiviral vector system consisting of a packaging vector (pHP) and a transducing vector …

We constructed five chimeric clones between human immunodeficiency virus type 1 (HIV-1)
and simian immunodeficiency virus (SIVMAC) and four SIVMAC mutants by recombinant …