The improvement of gene transfer efficiency in growth-arrested cells using human
immunodeficiency virus type 1 (HIV-1)-derived vectors led to the development of vectors …

The ultimate success of gene therapy to cure inherited or acquired genetic diseases relies
on the development and on the availability of gene transfer vectors that can efficiently deliver …

The human immunodeficiency virus (HIV) genome is AU rich, and this imparts a codon bias
that is quite different from the one used by human genes. The codon usage is particularly …

We analyzed virus sequences in two monkeys infected with SIVmac239 and two monkeys
infected with SHIVnef that maintained high, persisting viral loads. Sequence changes were …

Simian immunodeficiency virus (SlV mac) infectious for rhesus monkeys was altered by site-
directed mutagenesis of genes influencing in vivo replication and persistence with the long …

We have generated simplified simian immunodeficiency virus (SIV) constructs lacking the
nef, vpr, vpx, vif, tat, and rev genes (Δ6 viruses). To accomplish this, we began with an …

Lentiviral vectors combine two useful vector properties: permanent integration and
transduction of nondividing cells. Replication-defective lentiviral vectors were originally …

Deletion mutants of simian immunodeficiency virus (SIVmac) which were unable to integrate
into host cells were generated by removing a portion of the integrase (IN) domain of the pol …

Lentiviral vectors have received much attention in recent years due to their ability to
efficiently transduce non-dividing cells. Of the lentiviruses HIV-2 and SIV offer several …

The so-called" nonessential" genes of primate lentiviruses can be deleted without
abrogating the ability of virus to replicate under at least some cell culture conditions. In …