This unit presents protocols outlining the methodology and techniques involved in the
construction and application of HIV‐1‐based lentiviral vector systems. Also described are …

We investigated genetic recombination of the human immunodeficiency virus (HIV) in a
tissue culture system. A clonal cell line expressing a single integrated HIV provirus with a …

Lentiviruses are unique in their ability to infect both dividing and non‐dividing cells. This
makes the vectors derived from them particularly useful for gene transfer into non‐dividing …

We report the design of a unique two‐plasmid production system for the first lentiviral vector
to be evaluated in humans, VRX496. VRX496 is an optimized VSV‐G pseudotyped vector …

Delivering attenuated lentivirus vaccines as proviral DNA would be simple and inexpensive.
Inoculation of macaques with wild-type simian immunodeficiency virus strain mac239 …

Lentiviral RNA genomes present a strong bias in their nucleotide composition with extremely
high frequencies of A nucleotide in human immunodeficiency virus type 1 (HIV-1) and …

Visna virus is a lentivirus which causes a slow progressive disease involving the immune
system and the central nervous system. To determine the role of the viral long terminal …

Nonintegrating lentiviral (NIL) vectors were produced from HIV-1-based lentiviral vectors by
introducing combinations of mutations made to disable the integrase protein itself and to …

We describe the generation and the characterization of new lentiviral vectors derived from
SIVmac251, a simian immunodeficiency virus (SIV). A methodical approach was used to …

We evaluated the ability of an integrase (IN)-defective self-inactivating lentiviral vector
(sinLV) for the delivery of human immunodeficiency virus-1 (HIV-1) envelope sequences in …