Cyclooxygenase-2 (COX-2) is being intensively evaluated as a pharmacologic target for
both the prevention and treatment of cancer. Aberrant COX-2 expression was initially …

Abstract Cyclooxygenase2 (COX-2), an inducible prostaglandin G/H synthase, is
overexpressed in several human cancers. Here, the potential utility of selective COX-2 …

Prior to the discovery of cyclooxygenase-2 (COX-2), a beneficial association was shown
between chronic usage of non steroidal anti-inflammatory drugs (NSAIDs), that …

Several lines of evidence suggest that cyclooxygenase-2 (COX-2) is a rational target for
anticancer therapy. Epidemiological studies have shown that use of nonsteroidal anti …

Cyclooxygenase (COX)-2, an inducible enzyme involved in prostaglandin biosynthesis, has
attracted considerable attention recently, due to its role in human cancer biology. Several …

Cyclooxygenase (COX) inhibitors are being developed as potential agents for the
prevention and treatment of cancer after a century of widespread use for inflammation, fever …

Cyclooxygenase (COX) enzyme-dependent arachidonic acid metabolites occupy key
positions in important physiologic processes such as immunity, reproduction, and vascular …

Cyclooxygenase-2 (COX-2), an inducible prostaglandin synthase, is normally expressed in
parts of the kidney and brain. Aberrant COX-2 expression was first reported in colorectal …

A major goal in the area of cancer prevention and treatment is to make rational use of
defined molecular targets in order to block carcinogenesis. Studies conducted in …

Tumorigenesis is a complex process, and understanding the mechanisms behind
tumorigenesis is key to identifying effective targeted therapies. Prostaglandins are signaling …