Dietary feeding of grape seed extract prevents intestinal tumorigenesis in APCmin/+ mice

B Velmurugan, RP Singh, N Kaul, R Agarwal… - Neoplasia, 2010 - Elsevier
Chemopreventive effects and associated mechanisms of grape seed extract (GSE) against
intestinal/colon cancer development are largely unknown. Herein, we investigated GSE …

Grape Seed Extract Inhibits In vitro and In vivo Growth of Human Colorectal Carcinoma Cells

M Kaur, RP Singh, M Gu, R Agarwal, C Agarwal - Clinical Cancer Research, 2006 - AACR
Purpose: Accumulating evidences suggest the beneficial effects of fruit-and-vegetable
consumption in lowering the risk of various cancers, including colorectal cancer. Herein, we …

Grape antioxidant dietary fiber inhibits intestinal polyposis in Apc Min/+ mice: relation to cell cycle and immune response

S Sánchez-Tena, D Lizárraga, A Miranda… - …, 2013 - academic.oup.com
Epidemiological and experimental studies suggest that fiber and phenolic compounds might
have a protective effect on the development of colon cancer in humans. Accordingly, we …

Dietary‐feeding of grape seed extract prevents azoxymethane‐induced colonic aberrant crypt foci formation in fischer 344 rats

B Velmurugan, RP Singh, R Agarwal… - Molecular …, 2010 - Wiley Online Library
Chemoprevention by dietary agents/supplements has emerged as a novel approach to
control various malignancies, including colorectal cancer (CRC). This study assessed …

Grape seed extract induces cell cycle arrest and apoptosis in human colon carcinoma cells

M Kaur, R Mandair, R Agarwal, C Agarwal - Nutrition and cancer, 2008 - Taylor & Francis
One approach to control colorectal cancer (CRC) is its preventive intervention by dietary
agents or those consumed as supplements. However, because most of these products are …

Grape pomace inhibits colon carcinogenesis by suppressing cell proliferation and inducing epigenetic modifications

Q Tian, Z Xu, X Sun, J Deavila, M Du, M Zhu - The Journal of Nutritional …, 2020 - Elsevier
Grape pomace (GP), a by-product of the wine and juice industry, is rich in bioflavonoids and
dietary fibers. We hypothesized that GP has protective effects against colitis-associated …

Grape seed extract efficacy against azoxymethane-induced colon tumorigenesis in A/J mice: interlinking miRNA with cytokine signaling and inflammation

MM Derry, K Raina, V Balaiya, AK Jain… - Cancer prevention …, 2013 - AACR
Colorectal cancer (CRC) is the second leading cause of cancer-associated deaths,
suggesting that additional strategies are needed to prevent/control this malignancy. As CRC …

A flavonoid-rich extract from bergamot juice prevents carcinogenesis in a genetic model of colorectal cancer, the Pirc rat (F344/NTac-Apcam1137)

M Navarra, AP Femia, A Romagnoli, K Tortora… - European journal of …, 2020 - Springer
Purpose To determine the potential of a flavonoid-rich extract from bergamot juice (BJe) to
prevent colorectal carcinogenesis (CRC) in vivo. Main methods Pirc rats (F344/NTac-Apc …

Grape seeds and skin induce tumor growth inhibition via G1-phase arrest and apoptosis in mice inoculated with Ehrlich ascites carcinoma

NKB El-Din, DA Ali, RF Abou-El-Magd - Nutrition, 2019 - Elsevier
Objectives Chemoprevention or intervention of cancer by means of natural dietary
components has shown great promise in controlling malignancy. This study was conducted …

Grape seeds: ripe for cancer chemoprevention

SK Katiyar, M Athar - Cancer Prevention Research, 2013 - AACR
A wide variety of phytochemicals, mostly flavonoids or polyphenolics, have been shown to
possess anticarcinogenic activities. Among these are the grape seed proanthocyanidins …