The clinical relevance of high P-selectin levels in venous thrombosis is unknown. We
prospectively followed 544 patients with first unprovoked venous thromboembolism (VTE) …

Deep vein thrombosis (DVT) is associated with coagulation abnormalities, but evidence of
excess platelet activity is scant. Soluble P‐selectin is a marker of platelet activity, with high …

Venous thromboembolism is a very common and costly health problem worldwide.
Anticoagulant treatment for VTE is imperfect: all have the potential for significant bleeding …

Cancer patients are at high risk for venous thromboembolism (VTE). Laboratory parameters
with a predictive value for VTE could help stratify patients into high-or low-risk groups. The …

P-selectin is a 140 kD protein found in the α-granules of platelets and the Weibel-Palade
bodies of endothelial cells. On cell activation it is expressed on the cell surface and also …

Background Risk factors for atherosclerosis and venous thromboembolism (VTE) overlap
and are mostly associated with endothelial dysfunction (ED). We hypothesized that ED is …

P-Selectin represents a cell surface glycoprotein that is constitutively present in the Weibel-
Palade bodies of endothelial cells and in the α-granules of platelets. In inflam mation and …

Fig. 1 Dot plot showing increased levels of soluble P-selectin in patients who suffered a
cardiovascular end point (median 294 ng/ml, range 185-930 ng/ml) compared to those who …

Abstract Soluble P-selectin (CD62P) may arise from platelets, the endothelium, or both, and
raised levels are found in those with thrombotic disease and atherosclerosis. To determine …

Background The single nucleotide polymorphism (SNP) Ser128Argin the E-selectin gene is
overrepresented in certain patient populations with atherosclerosis or restenosis. As this …