[HTML][HTML] Antiphospholipid antibodies induce proinflammatory and procoagulant pathways in endothelial cells

M Patsouras, E Alexopoulou, S Foutadakis… - Journal of Translational …, 2023 - Elsevier
Antiphospholipid syndrome (APS) is an autoimmune thrombophilia characterized by
recurrent thrombotic events and/or pregnancy morbidity in the presence of antiphospholipid …

[HTML][HTML] Gene expression profiling identifies distinct molecular signatures in thrombotic and obstetric antiphospholipid syndrome

VM Ripoll, F Pregnolato, S Mazza, C Bodio… - Journal of …, 2018 - Elsevier
Antiphospholipid antibodies (aPL) cause vascular thrombosis (VT) and/or pregnancy
morbidity (PM). Differential mechanisms however, underlying the pathogenesis of these …

Mechanisms of action of the antiphospholipid antibodies

CB Chighizola, E Raschi, MO Borghi… - Handbook of Systemic …, 2017 - Elsevier
Antiphospholipid antibodies (aPL) not only are diagnostic biomarkers of antiphospholipid
syndrome (APS), but also exert a pathogenic role in mediating both thrombotic and obstetric …

Complement activation in anti-phospholipid syndrome: a clue for an inflammatory process?

I Cavazzana, N Manuela, C Irene, A Barbara… - Journal of …, 2007 - Elsevier
Anti-phospholipid syndrome (APS) is defined by recurrent arterial/venous thrombosis and/or
fetal losses in the persistent presence of anti-phospholipid antibodies (aPL). In in vivo …

T cell involvement in antiphospholipid syndrome

MG Tektonidou, NI Vlachogiannis, PP Sfikakis - Clinical Immunology, 2024 - Elsevier
Antiphospholipid syndrome (APS) is a systemic autoimmune disorder characterized by
arterial and venous thrombosis, and obstetric complications in the presence of …

Endothelium as a target for antiphospholipid antibodies

P Riboldi, M Gerosa, E Raschi, C Testoni, PL Meroni - Immunobiology, 2003 - Elsevier
Several, and not necessarily alternative, pathogenic mechanisms have been suggested to
sustain the thrombophilic diathesis of the anti-phospholipid syndrome. Among them …

Mechanisms of action of antiphospholipid antibodies

E Raschi, V Broggini, C Grossi, MO Borghi… - Handbook of Systemic …, 2009 - Elsevier
Antiphospholipid antibodies (aPL) are both diagnostic and pathogenic antibodies. aPL
may:(1) interfere with anticoagulant mechanisms and fibrinolysis favoring a prothrombotic …

A toggle switch linking coagulation and innate immunity in antiphospholipid antibody syndrome

D Roccatello, S Sciascia - Kidney International, 2021 - kidney-international.org
The antiphospholipid syndrome (APS) is defined by the occurrence of thrombotic events or
adverse pregnancy outcomes in individuals who persistently test positive for …

[HTML][HTML] Differences in endothelial activation and dysfunction induced by antiphospholipid antibodies among groups of patients with thrombotic, refractory, and non …

M Velásquez, LF Peláez, M Rojas… - Frontiers in …, 2021 - frontiersin.org
Antiphospholipid syndrome (APS) is an autoimmune disorder characterized by pregnancy
morbidity or thrombosis and persistent antiphospholipid antibodies (aPL) that bind to the …

Some recent insights into the prothrombogenic mechanisms of antiphospholipid antibodies

M Todorova, M Baleva - Current medicinal chemistry, 2007 - ingentaconnect.com
Antiphospholipid antibodies (aPL) are a heterogeneous group of autoantibodies, detected in
the sera of patients with both autoimmune and various non-autoimmune diseases. They are …