Background Leukaemia cells differ from their normal counterparts in that their ability to
properly regulate survival, proliferation, differentiation, and apoptosis is aberrant …

Ceramide is a sphingolipid that activates stress kinases such as p38 and c-JUN N-Terminal
Kinase (JNK). Though Chronic Myelogenous Leukemia (CML) derived K562 cells resist …

Ceramide metabolism has emerged as a potential target for anticancer therapy. Here, the
potential usefulness of two novel synthetic ceramide analogs as anti-leukemic drugs was …

While ceramide has emerged as a potent signal transducer, inconsistencies in the kinetics of
ceramide generation, or its absence, in response to stimuli have led to confusion and …

Abstract C 2-ceramide, a cell-permeable analogue of ceramide, induced significant, dose-
and time-dependent death in human retinoblastoma Y79 cells. Dying cells strongly …

Ceramide induces apoptosis in leukemia cell lines and has been proposed as a potential
therapeutic agent in malignancies refractory to conventional treatment. Here we show that …

In the preceding report we demonstrated that MCF-7-AdrR cells (adriamycin resistant) were
insensitive to ceramide, whereas MCF-7 wild-type cells were sensitive. It was also shown …

It is well known that tumor formation arises from the imbalance between cell death and
proliferation. For many years, cancer research has engaged an important part of its efforts to …

Ceramide, a product of sphingomyelin turn-over, has been proposed as a novel lipid second
messenger with specific roles in mediating antiproliferative responses including apoptosis …

The sphingolipid messenger ceramide has been implicated in the initiation of apoptotic cell
death in a variety of physiologic settings. Recent investigation has shown that ceramide …