Mathematical model of heterogeneous cancer growth with an autocrine signalling pathway

GM Hu, CY Lee, YY Chen, NN Pang… - Cell proliferation, 2012 - Wiley Online Library
Objectives Cancer is a complex biological occurrence which is difficult to describe clearly
and explain its growth development. As such, novel concepts, such as of heterogeneity and …

Relevance of microenvironmental pH for self-organized tumor growth and invasion.

M Kraus, T Severin, B Wolf - Anticancer research, 1994 - europepmc.org
The process of tumor cell growth, invasion and metastasis involves a self-organized
cascade of multiple tumor-host and tumor-immune interactions. The prediction of cancer …

[图书][B] Scheduling of angiogenic inhibitors for Gompertzian and logistic tumor growth models

U Ledzewicz, J Munden, HM Schättler - 2009 - Citeseer
The problem of scheduling a given amount of angiogenic inhibitors is considered as an
optimal control problem with the objective of maximizing the achievable tumor reduction. For …

Onsager's variational principle in proliferating biological tissues, in the presence of activity and anisotropy

J Ackermann, M Ben Amar - The European Physical Journal Plus, 2023 - Springer
A hallmark of biological cells is their ability to proliferate and of tissues their ability to grow.
This is common in morphogenesis and embryogenesis, but also in pathological conditions …

Chemo-elastic modeling of invasive carcinoma development accompanied by oncogenic epithelial-mesenchymal transition

DA Bratsun, IV Krasnyakov, L Pismen - AIP Conference Proceedings, 2017 - pubs.aip.org
We present a further development of a multiscale chemo-mechanical model of carcinoma
growth in the epithelium tissue proposed earlier. The epithelium is represented by an elastic …

Discrete and continuum phenotype-structured models for the evolution of cancer cell populations under chemotherapy

REA Stace, T Stiehl, MAJ Chaplain… - … Modelling of Natural …, 2020 - mmnp-journal.org
We present a stochastic individual-based model for the phenotypic evolution of cancer cell
populations under chemotherapy. In particular, we consider the case of combination cancer …

Cahn–Hilliard–Brinkman model for tumor growth with possibly singular potentials

P Colli, G Gilardi, A Signori, J Sprekels - Nonlinearity, 2023 - iopscience.iop.org
We analyze a phase field model for tumor growth consisting of a Cahn–Hilliard–Brinkman
system, ruling the evolution of the tumor mass, coupled with an advection-reaction-diffusion …

[HTML][HTML] Basic ingredients for mathematical modeling of tumor growth in vitro: cooperative effects and search for space

FHS Costa, M Campos, OE Aiéllo… - Journal of theoretical …, 2013 - Elsevier
Based on the literature data from HT-29 cell monolayers, we develop a model for its growth,
analogous to an epidemic model, mixing local and global interactions. First, we propose and …

Viscoelastic Cahn–Hilliard models for tumor growth

H Garcke, B Kovács, D Trautwein - Mathematical Models and …, 2022 - World Scientific
We introduce a new phase field model for tumor growth where viscoelastic effects are taken
into account. The model is derived from basic thermodynamical principles and consists of a …

[图书][B] Mathematical Oncology 2013

A d'Onofrio, A Gandolfi, A D'Onofrio - 2014 - Springer
After a long incubation period in which only sporadic investigations were devoted to the
applications of mathematics and physics to the study of tumors (see, eg, the work of Doll and …