[HTML][HTML] Intratumoral hydrogen peroxide with radiation therapy in locally advanced breast cancer: results from a phase 1 clinical trial

S Nimalasena, L Gothard, S Anbalagan, S Allen… - International Journal of …, 2020 - Elsevier
Purpose Hydrogen peroxide (H 2 O 2) plays a vital role in normal cellular processes but at
supraphysiological concentrations causes oxidative stress and cytotoxicity, a property that is …

Combination therapy with hydrogen peroxide and irradiation promotes an abscopal effect in mouse models

N Kemmotsu, L Zhu, J Nagasaki, Y Otani… - Cancer …, 2023 - Wiley Online Library
Abstract Hydrogen peroxide (H2O2) induces oxidative stress and cytotoxicity, and can be
used for treating cancers in combination with radiotherapy. A product comprising H2O2 and …

Hyperbaric oxygen therapy and late local toxic effects in patients with irradiated breast cancer: a randomized clinical trial

DRM van der Molen, MCT Batenburg, W Maarse… - JAMA …, 2024 - jamanetwork.com
Importance Hyperbaric oxygen therapy (HBOT) is proposed as treatment for late local toxic
effects after breast irradiation. Strong evidence of effectiveness is lacking. Objective To …

Successful treatment of radiation induced breast ulcer with hyperbaric oxygen

M Borg, D Wilkinson, V Humeniuk, J Norman - The Breast, 2001 - Elsevier
The purpose of this report was to investigate the efficacy of hyperbaric oxygen treatment in
the management of a persisting radiation induced ulcer following standard breast irradiation …

Hyaluronic acid optimises therapeutic effects of hydrogen peroxide‐induced oxidative stress on breast cancer

A Abbasi, N Pakravan… - Journal of Cellular …, 2021 - Wiley Online Library
Distinguishing the multiple effects of reactive oxygen species (ROS) on cancer cells is
important to understand their role in tumour biology. On one side, ROS can be oncogenic by …

[HTML][HTML] Hyperbaric oxygen therapy for late radiation-induced tissue toxicity: prospectively patient-reported outcome measures in breast cancer patients

DN Teguh, R Bol Raap, H Struikmans, C Verhoef… - Radiation …, 2016 - Springer
Introduction This study examines patient reported outcome measures of women undergoing
hyperbaric oxygen treatment (HBOT) after breast-conserving therapy. Method Included were …

Alleviating morbidity from locally advanced breast cancer using a practical and short radiation therapy regimen: results of the HYPORT palliative studies

S Chatterjee, S Chakrabarty, R Santosham… - International Journal of …, 2023 - Elsevier
Purpose Locally advanced breast cancers lead to debilitating local symptoms. Treatment of
these women encountered commonly in less resourced countries is not backed by strong …

[HTML][HTML] Paradigm Shift in Radiation Biology/Radiation Oncology—Exploitation of the “H2O2 Effect” for Radiotherapy Using Low-LET (Linear Energy Transfer) …

Y Ogawa - Cancers, 2016 - mdpi.com
Most radiation biologists/radiation oncologists have long accepted the concept that the
biologic effects of radiation principally involve damage to deoxyribonucleic acid (DNA) …

[HTML][HTML] Development of a novel enzyme-targeting radiosensitizer (KORTUC) containing hydrogen peroxide for intratumoral injection for patients with low linear …

S Tokuhiro, Y Ogawa, K Tsuzuki… - Oncology …, 2010 - spandidos-publications.com
The therapeutic effect of radiotherapy using linear accelerators for relatively large tumors of
more than several centimeters in diameter is reduced to one third due to a large number of …

[HTML][HTML] Hyperbaric oxygen therapy for local late radiation toxicity in breast cancer patients: A systematic review

EL Meier, DRM van der Molen, CA Lansdorp… - The Breast, 2023 - Elsevier
Purpose This systematic review aims to provide an overview of the literature on the effect of
hyperbaric oxygen therapy (HBOT) on symptoms of local late radiation toxicity (LRT) in …