Objective Osteoarthritis (OA) is polygenic with over 90 independent genome-wide
association loci so far reported. A key next step is the identification of target genes and the …

Objective To investigate whether the changes in collagen gene expression in osteoarthritic
(OA) human chondrocytes are associated with changes in the DNA methylation status in the …

Epigenetics can contribute to pathogenic mechanisms in autoimmunity, and we recently
identified an imprinted DNA methylation pattern in rheumatoid arthritis (RA) fibroblast-like …

Objectives To identify novel DNA methylation sites significant for rheumatoid arthritis (RA)
and comprehensively understand their underlying pathological mechanism. Methods We …

The dedifferentiation of hyaline chondrocytes into fibroblastic chondrocytes often
accompanies monolayer expansion of chondrocytes in vitro. The global DNA methylation …

Epigenetic regulation plays a crucial role in the pathogenesis of autoimmune diseases such
as inflammatory arthritis. DNA hypomethylating agents, such as decitabine (DAC), have …

In this study, we analyzed the methylation status of human promoters in rheumatoid arthritis
synovial fibroblasts (RASF). Differentially methylated genes between RASF and …

Objective To determine whether altered IL8 methylation status is associated with increased
expression of IL8 in human osteoarthritic (OA) chondrocytes. Methods IL8 expression levels …

5-Hydroxymethylcytosine (5-hmC) generated by ten-eleven translocation 1–3 (TET1–3)
enzymes is an epigenetic mark present in many tissues with different degrees of abundance …

Objective Rheumatoid arthritis (RA) is a chronic systemic autoimmune disease that mainly
targets joints. Monocytes and macrophages are critical in RA pathogenesis and contribute to …