Cystic fibrosis (CF) is caused by defective cyclic AMP-dependent cystic fibrosis
transmembrane conductance regulator Cl-channels. Thus, CF epithelia fail to transport Cl …

A postulated therapeutic avenue in cystic fibrosis (CF) is activation of Ca2+-dependent Cl−
channels via stimulation of Ca2+ entry from extracellular solutions independent of CFTR …

Human airway serous cells secrete antibiotic-rich fluid, but, in cystic fibrosis (CF), Cl−-
dependent fluid secretion is impaired by defects in CF transmembrane conductance …

A new family of Cl–channels widely expressed in epithelia has been identified. These
proteins are associated with Ca2+-sensitive conductive Cl–transport when heterologously …

In many cells, increase in intracellular calcium ([Ca2+] i) activates a Ca2+-dependent
chloride (Cl−) conductance (CaCC). CaCC is enhanced in cystic fibrosis (CF) epithelial cells …

Retention of F508del-CFTR proteins in the endoplasmic reticulum (ER) is dependent upon
chaperone proteins, many of which require Ca2+ for optimal activity. Here, we show in …

Chloride secretion across cystic fibrosis (CF) airway epithelia is effectively regulated by
pathways associated with intracellular Ca2+ metabolism, but not by mechanisms dependent …

Vitamin C (l-ascorbate) is present in the respiratory lining fluid of human lungs, and local
deficits occur during oxidative stress. Here we report a unique function of vitamin C on the …

The cystic fibrosis transmembrane conductance regulator (CFTR) functions to regulate both
CI− and Na+ conductive pathways; however, the cellular mechanisms whereby CFTR acts …

Loss of cystic fibrosis transmembrane conductance regulator (CFTR) anion channel function
causes cystic fibrosis (CF) lung disease. CFTR is expressed in airway epithelia, but how CF …