Hypoxemia is a defining feature of acute respiratory distress syndrome (ARDS), an often-
fatal complication of pulmonary or systemic inflammation, yet the resulting tissue hypoxia …

Acute lung injury (ALI) is a severe form of hypoxic lung disease responsible for a large
number of deaths worldwide. Despite recent advances in supportive care, no reduction in …

Rationale: Acute respiratory distress syndrome is defined by the presence of systemic
hypoxia and consequent on disordered neutrophilic inflammation. Local mechanisms …

Acute lung injury (ALI) is characterized by non-cardiogenic diffuse alveolar damage and
often leads to a lethal consequence, particularly when hypoxia coexists. The treatment of ALI …

Background The acute respiratory distress syndrome (ARDS) represents a form of severe
acute inflammatory lung disease. We have previously demonstrated significantly raised …

Supplemental oxygen is often required in the treatment of critically ill patients. The impact of
hyperoxia on pulmonary host defense is not well-established. We hypothesized that …

Under normal physiological conditions, the lung remains an oxygen rich environment.
However, prominent regions of hypoxia are a common feature of infected and inflamed …

Acute respiratory distress syndrome (ARDS) is a common respiratory critical syndrome with
no effective therapeutic intervention. Neutrophils function in the overwhelming inflammatory …

Oxygen therapy using mechanical ventilation with hyperoxia is necessary to treat patients
with respiratory failure and distress. However, prolonged exposure to hyperoxia leads to the …

The acute respiratory distress syndrome (ARDS) is a form of severe hypoxemic respiratory
failure that is characterized by inflammatory injury to the alveolar capillary barrier, with …