Microfluidic-based vascularized microphysiological systems

S Lee, J Ko, D Park, SR Lee, M Chung, Y Lee… - Lab on a Chip, 2018 - pubs.rsc.org
Microphysiological systems have emerged in the last decade to provide an alternative to in
vivo models in basic science and pharmaceutical research. In the field of vascular biology, in …

Vasculature-on-a-chip for in vitro disease models

S Kim, W Kim, S Lim, JS Jeon - Bioengineering, 2017 - mdpi.com
Vascularization, the formation of new blood vessels, is an essential biological process. As
the vasculature is involved in various fundamental physiological phenomena and closely …

Engineering Organ-on-a-Chip Systems for Vascular Diseases

A Shakeri, Y Wang, Y Zhao, S Landau… - … , and vascular biology, 2023 - Am Heart Assoc
Vascular diseases, such as atherosclerosis and thrombosis, are major causes of morbidity
and mortality worldwide. Traditional in vitro models for studying vascular diseases have …

Vessel-on-a-chip models for studying microvascular physiology, transport, and function in vitro

SR Moses, JJ Adorno, AF Palmer… - American Journal of …, 2021 - journals.physiology.org
To understand how the microvasculature grows and remodels, researchers require
reproducible systems that emulate the function of living tissue. Innovative contributions …

Vascularized microfluidic organ-chips for drug screening, disease models and tissue engineering

T Osaki, V Sivathanu, RD Kamm - Current opinion in biotechnology, 2018 - Elsevier
Highlights•Several viable methods currently exist to create vascularized in vitro
tissues.•Progress has been made in developing systems that mimic specific organs or …

Modeling organ-specific vasculature with organ-on-a-chip devices

DSY Lin, F Guo, B Zhang - Nanotechnology, 2018 - iopscience.iop.org
Organ-on-a-chip devices, also known as microphysiological systems, have gained
significant attention in recent years. Recent advances in tissue engineering and …

Microfluidic and organ-on-a-chip approaches to investigate cellular and microenvironmental contributions to cardiovascular function and pathology

EL Doherty, WY Aw, AJ Hickey… - … in Bioengineering and …, 2021 - frontiersin.org
Over the past decade, advances in microfabrication and biomaterials have facilitated the
development of microfluidic tissue and organ models to address challenges with …

The vascular niche in next generation microphysiological systems

ML Ewald, YH Chen, AP Lee, CCW Hughes - Lab on a Chip, 2021 - pubs.rsc.org
In recent years, microphysiological system (MPS, also known as, organ-on-a-chip or tissue
chip) platforms have emerged with great promise to improve the predictive capacity of …

Recent advances in microfluidic-based microphysiological systems

SM Kang - BioChip Journal, 2022 - Springer
Microphysiological systems are in vitro tissue and organ models that present unique
opportunities across different disciplines, such as biology, medicine, and engineering …

Microfluidic technologies for vasculature biomimicry

C Hu, Y Chen, MJA Tan, K Ren, H Wu - Analyst, 2019 - pubs.rsc.org
Microfluidic technology has been extensively employed in biology and medicine since the
field emerged in the 1990s. By utilizing microfluidic approaches, a variety of vascular system …