Alterations in DNA methylation corresponding with lung inflammation and as a biomarker for disease development after MWCNT exposure

TA Brown, JW Lee, A Holian, V Porter… - …, 2016 - Taylor & Francis
Use of multi-walled carbon nanotubes (MWCNT) is growing which increases occupational
exposures to these materials. Their toxic potential makes it important to have an in-depth …

Multiwalled carbon nanotubes of varying size lead to DNA methylation changes that correspond to lung inflammation and injury in a mouse model

E Cole, JL Ray, S Bolten, RF Hamilton Jr… - Chemical Research …, 2019 - ACS Publications
Diversity in physicochemical properties of engineered multiwalled carbon nanotubes
(MWCNTs) increases the complexity involved in interpreting toxicity studies of these …

[HTML][HTML] Multi-walled carbon nanotubes elicit concordant changes in DNA methylation and gene expression following long-term pulmonary exposure in mice

G Scala, MN Delaval, SP Mukherjee, A Federico… - Carbon, 2021 - Elsevier
Pulmonary exposure to multi-walled carbon nanotubes (MWCNTs) causes inflammation and
fibrosis. Our previous work has shown that industrially produced MWCNTs trigger specific …

Changes in DNA methylation induced by multi-walled carbon nanotube exposure in the workplace

M Ghosh, D Öner, K Poels, AM Tabish… - …, 2017 - Taylor & Francis
This study was designed to assess the epigenetic alterations in blood cells, induced by
occupational exposure to multi-wall carbon nanotubes (MWCNT). The study population …

DNA methylation changes in human lung epithelia cells exposed to multi-walled carbon nanotubes

MI Sierra, L Rubio, GF Bayón, I Cobo… - …, 2017 - Taylor & Francis
Humans are increasingly exposed to nanoparticles and, although many of their
physiological effects have been described, the molecular mechanisms underlying them are …

Differences in MWCNT-and SWCNT-induced DNA methylation alterations in association with the nuclear deposition

D Öner, M Ghosh, H Bové, M Moisse, B Boeckx… - Particle and fibre …, 2018 - Springer
Background Subtle DNA methylation alterations mediated by carbon nanotubes (CNTs)
exposure might contribute to pathogenesis and disease susceptibility. It is known that both …

[HTML][HTML] Toxicogenomics analysis of dynamic dose-response in macrophages highlights molecular alterations relevant for multi-walled carbon nanotube-induced lung …

LA Saarimäki, PAS Kinaret, G Scala, G del Giudice… - NanoImpact, 2020 - Elsevier
Toxicogenomics approaches are increasingly used to gain mechanistic insight into the
toxicity of engineered nanomaterials (ENMs). These emerging technologies have been …

Changes in DNA methylation in mouse lungs after a single intra-tracheal administration of nanomaterials

AM Tabish, K Poels, HM Byun, K Luyts, AA Baccarelli… - PloS one, 2017 - journals.plos.org
Aims This study aimed to investigate the effects of nanomaterial (NM) exposure on DNA
methylation. Methods and Results Intra-tracheal administration of NM: gold nanoparticles …

Low-dose carbon-based nanoparticle-induced effects in A549 lung cells determined by biospectroscopy are associated with increases in genomic methylation

J Li, M Tian, L Cui, J Dwyer, NJ Fullwood, H Shen… - Scientific reports, 2016 - nature.com
Nanotechnology has introduced many manufactured carbon-based nanoparticles (CNPs)
into our environment, generating a debate into their risks and benefits. Numerous …

[HTML][HTML] Induction and recovery of CpG site specific methylation changes in human bronchial cells after long-term exposure to carbon nanotubes and asbestos

D Öner, M Ghosh, R Coorens, H Bové, M Moisse… - Environment …, 2020 - Elsevier
Introduction Inhalation of asbestos induces lung cancer via different cellular mechanisms.
Together with the increased production of carbon nanotubes (CNTs) grows the concern …