Efflux is an important mechanism in Gram-negative bacteria conferring multidrug resistance.
Inhibition of efflux is an encouraging strategy to restore the antibacterial activity of antibiotics …

Efflux pumps of the resistance nodulation division (RND) superfamily, such as AcrB, make a
major contribution to multidrug resistance in Gram-negative bacteria. The development of …

Simple Summary Multidrug-resistant bacterial infections, especially that caused by Gram-
negative bacteria, have posed serious health issues worldwide. Bacteria have different …

The Escherichia coli AcrAB-TolC efflux pump is the archetype of the resistance nodulation
cell division (RND) exporters from Gram-negative bacteria. Overexpression of RND-type …

Efflux pumps of the Resistance Nodulation Division (RND) superfamily play a major role in
the intrinsic and acquired resistance of Gram-negative pathogens to antibiotics. Moreover …

Resistance–nodulation–division efflux pumps play a key role in inherent and evolved
multidrug resistance in bacteria. AcrB, a prototypical member of this protein family, extrudes …

Efflux transporters of the RND family confer resistance to multiple antibiotics in Gram-
negative bacteria. Here, we identify and chemically optimize pyridylpiperazine-based …

Multidrug efflux is a major contributor to antibiotic resistance in Gram-negative bacterial
pathogens. Inhibition of multidrug efflux pumps is a promising approach for reviving the …

The over-expression of multidrug efflux pumps belonging to the Resistance-Nodulation-
Division (RND) superfamily is one of the main causes of multidrug-resistance (MDR) in …

Gram-negative bacterial members of the Resistance Nodulation and cell Division (RND)
superfamily form tripartite efflux pump systems that span the cell envelope. One of the …