Pharmacokinetics of piperacillin–tazobactam: intermittent dosing versus continuous infusion
C Buck, N Bertram, T Ackermann, T Sauerbruch… - International journal of …, 2005 - Elsevier
In the present study 24 hospitalized patients requiring empirical antibiotic treatment were
randomly assigned to receive the β-lactam antibiotic/β-lactamase inhibitor combination …
randomly assigned to receive the β-lactam antibiotic/β-lactamase inhibitor combination …
Steady-state pharmacokinetics and pharmacodynamics of piperacillin/tazobactam administered by prolonged infusion in hospitalised patients
KM Shea, SC Cheatham, MF Wack, DW Smith… - International journal of …, 2009 - Elsevier
The objective of this study was to evaluate the steady-state pharmacokinetics and
pharmacodynamics of piperacillin/tazobactam, administered by prolonged infusion, in …
pharmacodynamics of piperacillin/tazobactam, administered by prolonged infusion, in …
Pharmacokinetics and pharmacodynamics of piperacillin/tazobactam when administered by continuous infusion and intermittent dosing
DS Burgess, T Waldrep - Clinical therapeutics, 2002 - Elsevier
Background: Although intermittent bolus dosing is currently the standard of practice for many
antimicrobial agents, beta-lactams exhibit time-dependent bacterial killing. Maximizing the …
antimicrobial agents, beta-lactams exhibit time-dependent bacterial killing. Maximizing the …
Pharmacokinetics and pharmacodynamics of two multiple-dose piperacillin-tazobactam regimens
DJ Occhipinti, SL Pendland… - Antimicrobial agents …, 1997 - Am Soc Microbiol
The pharmacokinetics and pharmacodynamics of two multiple-dose regimens of piperacillin-
tazobactam (3.375 g every 6 h and 4.5 g every 8 h) were evaluated at steady state for 12 …
tazobactam (3.375 g every 6 h and 4.5 g every 8 h) were evaluated at steady state for 12 …
Pharmacokinetic and pharmacodynamic evaluation of two dosing regimens for piperacillin‐tazobactam
MK Kim, B Capitano, HM Mattoes… - … : The Journal of …, 2002 - Wiley Online Library
Study Objective. To compare the pharmacokinetic and pharmacodynamic profiles of two
dosing regimens for piperacillin‐tazobactam against commonly encountered pathogens …
dosing regimens for piperacillin‐tazobactam against commonly encountered pathogens …
Pharmacokinetic and pharmacodynamic profile of high dose extended interval piperacillin–tazobactam
MK Kim, D Xuan, R Quintiliani… - Journal of …, 2001 - academic.oup.com
A multiple-dose, open-labelled, randomized, two period crossover human volunteer study
was performed (i) to describe the pharmacokinetic profile and safety profile of piperacillin …
was performed (i) to describe the pharmacokinetic profile and safety profile of piperacillin …
Pharmacodynamics of piperacillin alone and in combination with tazobactam against piperacillin-resistant and-susceptible organisms in an in vitro model of infection
AH Strayer, DH Gilbert, P Pivarnik… - Antimicrobial agents …, 1994 - Am Soc Microbiol
The pharmacodynamics of dosage regimens of piperacillin alone or in combination with
tazobactam against piperacillin-resistant or-susceptible bacteria were studied in an in vitro …
tazobactam against piperacillin-resistant or-susceptible bacteria were studied in an in vitro …
Clinical efficacy and pharmacoeconomics of a continuous‐infusion piperacillin‐tazobactam program in a large community teaching hospital
EM Grant, JL Kuti, DP Nicolau… - … : The Journal of …, 2002 - Wiley Online Library
Study Objective. To compare continuous versus intermittent administration of piperacillin‐
tazobactam with regard to clinical, microbiologic, and economic outcomes. Design …
tazobactam with regard to clinical, microbiologic, and economic outcomes. Design …
Pharmacokinetic-pharmacodynamic modelling of the in vitro antiinfective effect of piperacillin-tazobactam combinations.
T Dalla Costa, A Nolting, K Rand… - International journal of …, 1997 - europepmc.org
Purpose The aim of the study was to investigate the in vitro antiinfective effect of piperacillin-
tazobactam (PIP-TZB) combinations on Escherichia coli in simulations of free concentration …
tazobactam (PIP-TZB) combinations on Escherichia coli in simulations of free concentration …
Population pharmacokinetics of extended-infusion piperacillin-tazobactam in hospitalized patients with nosocomial infections
While extended infusions of piperacillin-tazobactam (TZP) are increasingly used in practice,
the effect of infusion on the pharmacokinetic (PK) profile of TZP has not been widely …
the effect of infusion on the pharmacokinetic (PK) profile of TZP has not been widely …
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