Ultrasensitive magnetic resonance imaging of systemic reactive oxygen species in vivo for early diagnosis of sepsis using activatable nanoprobes

H Wang, D Yu, B Li, Z Liu, J Ren, X Qu - Chemical Science, 2019 - pubs.rsc.org
Current diagnostic methods for sepsis lack required speed or precision, often failing to make
timely accurate diagnosis for early medical treatment. The systemic excess generation of …

Sensitive activatable nanoprobes for real‐time ratiometric magnetic resonance imaging of reactive oxygen species and ameliorating inflammation in vivo

X Li, Y Liu, X Qi, S Xiao, Z Xu, Z Yuan, Q Liu… - Advanced …, 2022 - Wiley Online Library
Imaging‐guided real‐time monitoring of the treatment process of inflammatory diseases is
important for the timely adjustment of treatment planning to lower unnecessary side effects …

Activatable Multiplexed 19F Magnetic Resonance Imaging Visualizes Reactive Oxygen and Nitrogen Species in Drug-Induced Acute Kidney Injury

A Li, X Luo, L Li, D Chen, X Liu, Z Yang… - Analytical …, 2021 - ACS Publications
In vivo levels of reactive oxygen species (ROS) and reactive nitrogen species (RNS) are
critical to many physiological and pathological processes. Because of the distinct differences …

Elucidating the Relationship between ROS and Protein Phosphorylation through In Situ Fluorescence Imaging in the Pneumonia Mice

W Zhang, J Ren, J Lu, P Li, W Zhang, H Wang… - Analytical …, 2021 - ACS Publications
Revealing the relationship between reactive oxygen species (ROS) and levels of protein
phosphorylation is of great significance for understanding the pathogenesis of diseases …

Design of a new near-infrared ratiometric fluorescent nanoprobe for real-time imaging of superoxide anions and hydroxyl radicals in live cells and in situ tracing of the …

R Liu, L Zhang, Y Chen, Z Huang, Y Huang… - Analytical …, 2018 - ACS Publications
The superoxide anion (O2•–) and hydroxyl radical (• OH) are important reactive oxygen
species (ROS) used as biomarkers in physiological and pathological processes. ROS …

Activatable superparamagnetic iron oxide nanoparticles scavenge reactive oxygen species in macrophages and endothelial cells

C Nwasike, E Yoo, E Purr, AL Doiron - RSC advances, 2020 - pubs.rsc.org
Reactive oxygen species (ROS) are key markers of inflammation, with varying levels of
superoxide indicating the degree of inflammation. Inflammatory diseases remain the leading …

Visualizing and quantifying acute inflammation using ICAM-1 specific nanoparticles and MRI quantitative susceptibility mapping

R Wong, X Chen, Y Wang, X Hu, MM Jin - Annals of biomedical …, 2012 - Springer
As intense and prolonged inflammation correlates with the progression of various
inflammatory diseases, locating specific regions of the body with dysregulated levels of …

Dynamically reversible iron oxide nanoparticle assemblies for targeted amplification of T1-weighted magnetic resonance imaging of tumors

F Li, Z Liang, J Liu, J Sun, X Hu, M Zhao, J Liu, R Bai… - Nano …, 2019 - ACS Publications
Smart magnetic resonance (MR) contrast agents, by which MR contrast can be selectively
enhanced under acidic tumor microenvironment, are anticipated to significantly improve the …

Introducing Specificity to Iron Oxide Nanoparticle Imaging by Combining 57Fe-Based MRI and Mass Spectrometry

M Masthoff, R Buchholz, A Beuker, L Wachsmuth… - Nano …, 2019 - ACS Publications
Iron oxide nanoparticles (ION) are highly sensitive probes for magnetic resonance imaging
(MRI) that have previously been used for in vivo cell tracking and have enabled …

Combined off‐resonance imaging and T2 relaxation in the rotating frame for positive contrast MR imaging of infection in a murine burn model

OC Andronesi, D Mintzopoulos… - Journal of Magnetic …, 2010 - Wiley Online Library
Purpose To develop novel magnetic resonance (MR) imaging methods to monitor
accumulation of macrophages in inflammation and infection. Positive‐contrast MR imaging …