Splitting birth defects into dysmorphologically homogeneous groups might improve the
ability to detect a genetic risk factor or teratogenic exposure. With regard to spina bifida …

Background Neural tube defects (NTDs) are caused by the failure of neural tube formation
which occurs during early embryonic development. NTDs are the most severe and leading …

Summary Shanxi province in Northern China has one of the highest reported prevalence
rates of neural tube defects (NTD) in the world. To explore the risk factors for NTDs in Shanxi …

Neural tube defects (NTDs) are a group of embryological malformations involving failure of
the neural tube to close during early development, resulting in spina bifida (SB) and …

There is growing evidence that epigenetic dysregulation plays a role in neurodevelopmental
disorders. In humans, folate is one of the main donors of the methyl group required for the …

Neural tube defects (NTDs) are the leading cause of infant deaths worldwide. Lipoprotein
related receptor 2 (LRP2) has been shown to play a crucial role in neural tube development …

Background Despite a substantial prevention of neural tube defects with mandatory folic
acid (FA) fortification, a significant number of cases still exist in Alberta, Canada, particularly …

Objectives Sex differences in prevalence of neural tube defects (NTDs) have previously
been recognised; however, the different susceptibility of men and women have not been …

Background The potential to reduce child mortality by preventing folic acid‐preventable
spina bifida and anencephaly (FAP SBA) is inadequately appreciated. To quantify possible …

Folic acid-preventable spina bifida and anencephaly are pandemic, affecting 225,000
children a year. These birth defects are as preventable as polio. As we near the eradication …