Accumulative studies revealed that E3 ubiquitin ligases have important roles in colorectal
carcinogenesis. The pathogenic mechanisms of colorectal cancer (CRC) initiation and …

Simple Summary We summarized and cataloged the E3 ligases involved in endometrial
carcinoma (EC) and cervical cancer (CC). Finally, an overview of the current drugs that …

Abstract Ring finger protein 11 (RNF11) is a small RING E3-ligase overexpressed in
numerous human prostate, colon and invasive breast cancers. Although functional studies …

The development of triple-negative breast cancer (TNBC) negatively impacts both quality of
life and survival in a high percentage of patients. Here, we show that RING finger protein …

The ubiquitin-proteasome system has numerous crucial roles in physiology and
pathophysiology. Fundamental to the specificity of this system are ubiquitin-protein ligases …

The E3 ubiquitin ligase ring finger protein 115 (RNF 115) is overexpressed in more than half
of human breast tumors and is implicated in the pathogenesis and progression of breast …

Abstract E6-associated protein (E6-AP) is a dual function protein. It acts as an E3 ubiquitin-
protein ligase enzyme and coactivator of steroid hormone receptors such as estrogen (ERα) …

E3 ubiquitin ligases are a large family of proteins that are engaged in the regulation of the
turnover and activity of many target proteins. Together with ubiquitinactivating enzyme El …

E3 ubiquitin ligases are a large family of proteins that can be classified into three major
structurally distinct types: N-end rule E3s, E3s containing the HECT (Homology to E6AP C …

Disregulation of the cell cycle and proliferation play key roles in cellular transformation and
tumorigenesis. Such processes are intimately tied to the concentration, localization and …