[HTML][HTML] An overview of the production methods for core–shell microspheres for parenteral controlled drug delivery

RS van der Kooij, R Steendam, HW Frijlink… - European Journal of …, 2022 - Elsevier
Core-shell microspheres hold great promise as a drug delivery system because they offer
several benefits over monolithic microspheres in terms of release kinetics, for instance a …

An overview of preparation and evaluation sustained-release injectable microspheres

L Hu, H Zhang, W Song - Journal of microencapsulation, 2013 - Taylor & Francis
Recently, sustained-release injectable microspheres as a novel parenteral administration
system have been interested on for many years, due to the excellent advantages when …

Recent advances in polymeric microspheres for parenteral drug delivery–part 1

S Mao, C Guo, Y Shi, LC Li - Expert opinion on drug delivery, 2012 - Taylor & Francis
Introduction: Polymeric microspheres have been established as a valuable parenteral drug
delivery system for sustained release of therapeutic agents via subcutaneous or …

Microencapsulation by solvent extraction/evaporation: reviewing the state of the art of microsphere preparation process technology

S Freitas, HP Merkle, B Gander - Journal of controlled release, 2005 - Elsevier
The therapeutic benefit of microencapsulated drugs and vaccines brought forth the need to
prepare such particles in larger quantities and in sufficient quality suitable for clinical trials …

Microfluidic fabrication of polymeric core-shell microspheres for controlled release applications

T Kong, J Wu, KWK Yeung, MKT To, HC Shum… - …, 2013 - pubs.aip.org
We report a facile and robust microfluidic method to fabricate polymeric core-shell
microspheres as delivery vehicles for biomedical applications. The characteristics of core …

Recent advances in polymeric microspheres for parenteral drug delivery—part 2

S Mao, C Guo, Y Shi, LC Li - Expert Opinion on Drug Delivery, 2012 - Taylor & Francis
Introduction: Currently marketed microsphere products are manufactured with the use of
organic solvents which have a negative impact on the environment and stability of biological …

Polymer microspheres for controlled drug release

S Freiberg, XX Zhu - International journal of pharmaceutics, 2004 - Elsevier
Polymer microspheres can be employed to deliver medication in a rate-controlled and
sometimes targeted manner. Medication is released from a microsphere by drug leaching …

Why and how to prepare biodegradable, monodispersed, polymeric microparticles in the field of pharmacy?

VT Tran, JP Benoît, MC Venier-Julienne - International journal of …, 2011 - Elsevier
Drug delivery via biodegradable microparticles benefits from both the protection of the
encapsulated drug from hazardous conditions and the controlled release of the …

Modified emulsion solvent evaporation method for fabricating core–shell microspheres

CD Xiao, XC Shen, L Tao - International journal of pharmaceutics, 2013 - Elsevier
Solvent evaporation/extraction method is widely used for core–shell microspheres
fabrication. However, the solvent evaporation rate, as an essential factor for polymers phase …

Preparation of monodisperse controlled release microcapsules

T Brandau - International Journal of Pharmaceutics, 2002 - Elsevier
Since the handling of many active agents in its pure form has many problems,
microencapsulation is used to have better properties in the product. With the patented …