Recent progress in microRNA delivery for cancer therapy by non-viral synthetic vectors

H Wang, Y Jiang, H Peng, Y Chen, P Zhu… - Advanced drug delivery …, 2015 - Elsevier
MicroRNAs (miRNAs) are small non-coding RNAs that regulate gene expression. Because
of significant changes in their expression in cancer, miRNAs are believed to be key factors in …

In vivo delivery of miRNAs for cancer therapy: challenges and strategies

Y Chen, DY Gao, L Huang - Advanced drug delivery reviews, 2015 - Elsevier
Abstract MicroRNAs (miRNAs), small non-coding RNAs, can regulate post-transcriptional
gene expressions and silence a broad set of target genes. miRNAs, aberrantly expressed in …

Progress in microRNA delivery

Y Zhang, Z Wang, RA Gemeinhart - Journal of controlled release, 2013 - Elsevier
MicroRNAs (miRNAs) are non-coding endogenous RNAs that direct post-transcriptional
regulation of gene expression by several mechanisms. Activity is primarily through binding …

miRNA delivery by nanosystems: state of the art and perspectives

FC Moraes, C Pichon, D Letourneur, F Chaubet - Pharmaceutics, 2021 - mdpi.com
MicroRNAs (miRNAs) are short (~ 21–23 nucleotides), non-coding endogenous RNA
molecules that modulate gene expression at the post-transcriptional level via the …

miRacle of microRNA-driven cancer nanotherapeutics

G Kara, B Arun, GA Calin, B Ozpolat - Cancers, 2022 - mdpi.com
Simple Summary The discovery of microRNAs has revolutionized the world of science and
opened up new opportunities in cancer treatment. miRNA dysregulation plays a crucial role …

Recent progress in microRNA-based delivery systems for the treatment of human disease

Y Fu, J Chen, Z Huang - ExRNA, 2019 - Springer
MicroRNAs (miRNAs) are naturally occurring, small non-coding RNAs that mediate
posttranscriptional regulation. Based on the level of sequence complementarity, miRNAs …

MicroRNA therapeutics in cancer: current advances and challenges

S Reda El Sayed, J Cristante, L Guyon, J Denis… - Cancers, 2021 - mdpi.com
Simple Summary Cancer is a complex disease associated with deregulation of numerous
genes. In addition, redundant cellular pathways limit efficiency of monotarget drugs in …

A comprehensive review of cancer MicroRNA therapeutic delivery strategies

A Forterre, H Komuro, S Aminova, M Harada - Cancers, 2020 - mdpi.com
In the field of molecular oncology, microRNAs (miRNAs) and their role in regulating
physiological processes and cancer pathogenesis have been a revolutionary discovery over …

Non-viral based miR delivery and recent developments

AE Labatut, G Mattheolabakis - European Journal of Pharmaceutics and …, 2018 - Elsevier
Abstract miRNAs are promising therapeutic targets or tools for the treatment of numerous
diseases, with most prominently, cancer. The inherent capacity of these short nucleic acids …

miRNA nanotherapeutics for cancer

A Ganju, S Khan, BB Hafeez, SW Behrman… - Drug discovery today, 2017 - Elsevier
Highlights•MicroRNAs play a major role in cancer.•Several clinical trials with microRNA are
reported for cancer treatment.•Delivery of microRNA encounters several challenges.•We …