There is now evidence that repeated administration of interferon-α (IFN-α) to patients with
chronic active hepatitis and cancers induces depressive symptoms. There is also evidence …

IFN alpha treatment is able to produce dose-related side effects, such as depression, in the
central nervous system. We assessed the effects on depression of four different types of IFN …

Immunotherapy with interferon-alpha (IFNα) may induce depressive symptoms, anxiety and
major depression when administered for at least 1–3 months at a dose of 3–10 MUI daily …

We have shown that treatment with interleukin-2 (IL-2) or interferon-α (IFNα) may induce
depressive symptoms and activation of the cytokine network and that IL-2 treatment may …

We studied 60 patients receiving a 1-year course of interferon (IFN)-αtherapy for chronic
viral hepatitis. Patients underwent psychiatric assessment before starting the IFN-αtherapy …

Thirty-nine patients with hepatitis C viral infection on interferon-α (IFN-α) therapy were
monitored weekly using the Beck Depression Inventory (BDI). Thirteen of thirty-nine patients …

Background: Several studies found a high incidence rate of neuro-psychiatric complications
during long-term therapy with interferon alpha (IFNα), eg slowness, severe fatigue …

Interferon (IFN) therapy has been associated with the development of Major Depressive
Disorder (MDD) when given to patients with hepatitis C (HCV). The incidence, time course …

Background: Psychiatric side effects are common during interferon-alfa (IFN-alfa) therapy
and often responsible for early treatment discontinuation, thus limiting its therapeutic …

OBJECTIVE: Proinflammatory cytokines have the potential to activate the hypothalamo-
pituitary-adrenocortical (HPA) axis, and HPA axis hyperactivity is also encountered in …